Evidence map›Paper›PMID 31105011›Full record

ArticleDevelopmental cell2019

Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian Clock.

Maria A Nohales, Wanlu Liu, Tomas Duffy, Kazunari Nozue, Mariko Sawa, Jose L Pruneda-Paz, Julin N Maloof, Steven E Jacobsen, Steve A Kay

Open access · bronzeAbstract read
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 79 citations in OpenAlex.

  1. Review
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  14. GIGANTEA adjusts the response to shade at dusk by directly impinging on PHYTOCHROME INTERACTING FACTOR 7 function.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. HOS15-mediated turnover of PRR7 enhances freezing tolerance.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
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  18. Genes · 2024
    Review
  19. Investigating Circadian Gating of Temperature Responsive Genes.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Maria A NohalesKeck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Wanlu LiuDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Zhejiang University, University of Edinburgh Institute, Zhejiang University School of Medicine, Hangzhou 310058, P.R. China.
Tomas DuffyKeck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Kazunari NozueDepartment of Plant Biology, University of California, Davis, Davis, CA 95616, USA.
Mariko SawaSection of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, San Diego, La Jolla, CA 92093, USA.
Jose L Pruneda-PazSection of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, San Diego, La Jolla, CA 92093, USA.
Julin N MaloofDepartment of Plant Biology, University of California, Davis, Davis, CA 95616, USA.
Steven E JacobsenDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Steve A KayKeck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: stevekay@usc.edu.
University of Southern California · USUniversity of California, Davis · USUniversity of California, Los Angeles · USUniversity of California, San Diego · US

Funding

GENETIC ANALYSIS OF CIRCADIAN RHYTHMS IN ARABIDOPSISR01GM056006 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A, PRUNEDA-PAZ, JOSE L · 1996 to 2016
$6.0M
Molecular Mechanisms in the Arabidopsis Circadian ClockR01GM067837 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAY, STEVE A · 2003 to 2015
$4.7M
Molecular Mechanisms in the Arabidopsis Circadian ClockR37GM067837 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI STEVE A KAY · 2017 to 2026
$4.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM056006NIGMS NIH HHS R01 GM067837NIGMS NIH HHS R37 GM067837
6 · The paper itself

Abstract

Integration of environmental signals with endogenous biological processes is essential for organisms to thrive in their natural environment. Being entrained by periodic environmental changes, the circadian clock incorporates external information to coordinate physiological processes, phasing them to the optimal time of the day and year. Here, we present a pivotal role for the clock component GIGANTEA (GI) as a genome-wide regulator of transcriptional networks mediating growth and adaptive processes in plants. We provide mechanistic details on how GI integrates endogenous timing with light signaling pathways through the global modulation of PHYTOCHROME-INTERACTING FACTORs (PIFs). Gating of the activity of these transcriptional regulators by GI directly affects a wide array of output rhythms, including photoperiodic growth. Furthermore, we uncover a role for PIFs in mediating light input to the circadian oscillator and show how their regulation by GI is required to set the pace of the clock in response to light-dark cycles.

Indexed as

Circadian RhythmGene Expression Regulation, PlantPhotoperiodArabidopsisArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsNicotianaPlant ProteinsSignal TransductionArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsGI protein, ArabidopsisPIF5 protein, ArabidopsisPlant ProteinsArabidopsiscircadian clockclock synchronizationGIGANTEAlight inputlight signalingoutputtranscriptional networks

Identifiers

PMID31105011
PMCPMC6597437
OpenAlexW2944859501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.