ArticleDevelopmental cell2019
Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate.
Open access · bronzeAbstract read
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Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 65 citations in OpenAlex.
- Integrated stress signaling pathways promote adaptive reprogramming for chondrocyte survival in Metaphyseal Chondrodysplasia Type Schmid.Bone research · 2026Article
- The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a during postnatal development.Development (Cambridge, England) · 2026Article
- Anti-Müllerian hormone promotes minichromosome maintenance protein expression and creatine metabolism in primate preantral follicles under hypoxia.Reproductive biology and endocrinology : RB&E · 2026Article
- Cellular mechanometabolism: stimuli and implications.EMBO reports · 2026Review
- Vertebral BMSC-EVs under estrogen deficiency drive senescence-related mitochondrial dysfunction in endplate chondrocytes via MRPL1 mRNA delivery.Experimental & molecular medicine · 2026Article
- Chondrocytes reprogram chromatin in hypoxic microenvironments to activate CADM1-AS1/HDAC1 complex-mediated anti-inflammation signals.Nature communications · 2026Article
- HIF-1α-centered metabolic reprogramming in osteoarthritis: cell type-specific effects and intercellular crosstalk among chondrocytes, BMSCs, and macrophages.Frontiers in immunology · 2026Review
- The developing tendon and enthesis are hypoxic and rely on hypoxia-inducible factor 1a (bioRxiv : the preprint server for biology · 2025Article
- Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes.Nature communications · 2025Article
- Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy.Journal of orthopaedic translation · 2025Article
- Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells.Osteoarthritis and cartilage open · 2025Article
- Increased oxidative phosphorylation through pyruvate dehydrogenase kinase 2 deficiency ameliorates cartilage degradation in mice with surgically induced osteoarthritis.Experimental & molecular medicine · 2025Article
- The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes.Nature metabolism · 2025Article
- Characterization of hypoxia-related molecular clusters and prognostic riskScore for glioma.Frontiers in oncology · 2025Article
- Up IGF-I via high-toughness adaptive hydrogels for remodeling growth plate of children.Regenerative biomaterials · 2025Article
- Single-cell RNA sequencing identifies the expression of hemoglobin in chondrocyte cell subpopulations in osteoarthritis.BMC molecular and cell biology · 2024Article
- Metabolic reprogramming in skeletal cell differentiation.Bone research · 2024Review
- HIF1 activation safeguards cortical bone formation against impaired oxidative phosphorylation.JCI insight · 2024Article
- Hedy: a groundbreaking revelation of cartilage oxygen homeostasis.Acta biochimica et biophysica Sinica · 2024Article
- Metabolic regulation of skeletal cell fate and function.Nature reviews. Endocrinology · 2024Review
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Authors and funding
11 authors at 3 institutions in 1 country.
Qing YaoDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Mohd Parvez KhanDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Christophe MerceronDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Edward L LaGoryDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zachary TataDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Laura MangiaviniDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Jiarui HuDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Krishna VemulapalliDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Navdeep S ChandelDepartments of Medicine and Cell Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Amato J GiacciaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ernestina SchipaniDepartments of Orthopaedic Surgery, Medicine, and Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. Electronic address: eschipan@med.umich.edu.
University of Michigan–Ann Arbor · USStanford University · USNorthwestern University · US
Funding
The Impact of Mitochondrial Repression and Lipid Accumulation by HIF on Tumor GrowthR35CA197713 · NCI · STANFORD UNIVERSITY · PI GIACCIA, AMATO J. · 2015 to 2021
$5.3MHIF-1alpha, a Survival and Differentiation Factor for CartilageR01AR065403 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHIPANI, ERNESTINA · 2013 to 2017
$1.7MNCI NIH HHS R35 CA197713NIAMS NIH HHS R01 AR065403
Abstract
Oxygen (O
Indexed as
AnimalsBasic Helix-Loop-Helix ProteinsCell RespirationCell SurvivalChondrocytesDNA-Binding ProteinsEndothelial PAS Domain-Containing Protein 1FemaleFetal DevelopmentGrowth PlateHigh Mobility Group ProteinsHomeodomain ProteinsHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMaleMiceBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsEndothelial PAS Domain-Containing Protein 1Hif1a protein, mouseHigh Mobility Group ProteinsHomeodomain ProteinsHypoxia-Inducible Factor 1, alpha SubunitPrrx1 protein, mouseTfam protein, mousecell deathchondrocytefetal developmentglycolysisgrowth plateHIFhypoxiamitochondriamitochondrial respirationTFAM
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.