Evidence map›Paper›PMID 31104957›Full record

SynthesisSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2019

Metabolic surgery improves renal injury independent of weight loss: a meta-analysis.

Katharina M Scheurlen, Pascal Probst, Stefan Kopf, Peter P Nawroth, Adrian T Billeter, Beat P Müller-Stich

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04626323 (Open, Randomized, Unicenter Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04626323 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Open, Randomized, Unicenter Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease

TypeinterventionalSponsorHospital Alemão Oswaldo CruzRan2021 to 2024Enrolled60ConditionsDiabetes Mellitus, Type 2, Kidney Disease, Chronic, Kidney InjuryArmsRoux-en-Y gastric bypass, Best medical treatment
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Observational
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. The relationship between kidney function and body mass index before and after bariatric surgery in patients with chronic kidney disease.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. [Quality of indications in bariatric surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2020
    Review
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katharina M ScheurlenDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Pascal ProbstDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Stefan KopfDepartment of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany.
Peter P NawrothDepartment of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany.
Adrian T BilleterDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Beat P Müller-StichDepartment of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. Electronic address: beat.mueller@med.uni-heidelberg.de.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetabolic surgery is the most effective therapy for patients with type 2 diabetes (T2D), also improving diabetic kidney disease. Whether these effects depend on weight loss is currently unknown.

objectivesTo assess the correlation between weight loss and improvement of diabetic kidney disease in patients with T2D undergoing metabolic surgery.

settingUniversity of Heidelberg, Germany.

methodsA systematic literature search was performed in December 2018 using the MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials databases without language restrictions or time limit. Studies reporting exact data on change in urinary albumin-creatinine ratio (uACR) or albuminuria as well as change in body mass index in patients with T2D undergoing metabolic surgery were included. Out of 2145 potentially eligible hits, 15 studies were included. Study quality was assessed using the Downs and Black score. Data were pooled using a random-effects model, and a Spearman's rank correlation was performed.

resultsNo correlation was found between improved renal injury (change in uACR or albuminuria) and weight loss (change in body mass index) (r

conclusionMetabolic surgery can improve diabetic kidney disease independent of weight loss and glycemic control. Other mechanisms, including modified adipokine balance, signaling pathways of fat tissue and gut hormones, or reduced systemic inflammation, contribute to improved renal injury, while weight loss seems to play a lesser role than expected.

Indexed as

Diabetic NephropathiesObesity, MorbidAdultBariatric SurgeryDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedWeight LossBariatric surgeryDiabetic nephropathyMetabolic surgeryMicrovascular complicationsWeight loss

Identifiers

PMID31104957
OpenAlexW2922777478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.