Evidence map›Paper›PMID 31104942›Full record

ArticleCell stem cell2019

Intracellular Ca

Matthew S MacDougall, Ryan Clarke, Bradley J Merrill

Open access · bronzeAbstract read
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Intercellular mRNA transfer alters the human pluripotent stem cell state.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Inter-cellular mRNA Transfer Alters Human Pluripotent Stem Cell State.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
  8. CaInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and Stemness.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. B3GALT5 knockout alters gycosphingolipid profile and facilitates transition to human naïve pluripotency.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew S MacDougallDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Ryan ClarkeDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Bradley J MerrillDepartment of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA; Genome Editing Core, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: merrillb@uic.edu.
University of Illinois Chicago · US

Funding

Wnt/Beta-catenin and Tcf/Lef factor regulation of pluripotencyR01HD081534 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MERRILL, BRADLEY J · 2014 to 2018
$1.6M
Elucidating the genetic determinants for exit out of pluripotency with a CRISPR-Cas9 genome-wide knockout screenF30HD090938 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MACDOUGALL, MATTHEW STEVEN · 2017 to 2020
$192k
NICHD NIH HHS F30 HD090938NICHD NIH HHS R01 HD081534
6 · The paper itself

Abstract

Progression through states of pluripotency is required for cells in early mammalian embryos to transition away from heightened self-renewal and toward competency for lineage specification. Here, we use a CRISPR mutagenesis screen in mouse embryonic stem cells (ESCs) to identify unexpected roles for nuclear export and intracellular Ca

Indexed as

Active Transport, Cell NucleusAnimalsCalcium SignalingCell DifferentiationCell LineageCell Self RenewalClustered Regularly Interspaced Short Palindromic RepeatsGlycogen Synthase Kinase 3HomeostasisIntracellular SpaceMiceMice, KnockoutMouse Embryonic Stem CellsNuclear ProteinsPlasma Membrane Calcium-Transporting ATPasesPluripotent Stem CellsAtp2b1 protein, mouseGlycogen Synthase Kinase 3Nuclear ProteinsPlasma Membrane Calcium-Transporting ATPasesran-binding protein 1Tcf7l1 protein, mouseTranscription Factor 7-Like 1 ProteinAtp2b1calcitonincalciumCRISPRembryonic stem cellnuclear exportpluripotencyRanbp3self-renewalTcf7l1

Identifiers

PMID31104942
PMCPMC6685429
OpenAlexW2944870578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.