ArticleCell2019
Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 78 citations in OpenAlex.
- Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.Nature communications · 2026Article
- Attachment Theory: Novel Clinical and Molecular Insights.Biomolecules · 2026Review
- Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity.eNeuro · 2025Article
- Article
- A genetically-defined population of amygdalofugal neurons promotes suckling and early postnatal growth.bioRxiv : the preprint server for biology · 2025Article
- Age-specific regulation of sociability by hypothalamic Agrp neurons.Current biology : CB · 2025Article
- Oxytocin signaling regulates maternally directed behavior during early life.Science (New York, N.Y.) · 2025Article
- Distinct neural representations of hunger and thirst in neonatal mice before the emergence of food- and water-seeking behaviors.Current biology : CB · 2025Article
- Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior.iScience · 2025Article
- Ontogeny of the vagal gut-brain axis.bioRxiv : the preprint server for biology · 2025Article
- A humanized NOVA1 splicing factor alters mouse vocal communications.Nature communications · 2025Article
- Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors.bioRxiv : the preprint server for biology · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- A normative framework dissociates need and motivation in hypothalamic neurons.Science advances · 2024Article
- Methodology for Studying Hypothalamic Regulation of Feeding Behaviors.Methods and protocols · 2024Review
- Prenatal exposure to valproic acid reduces synaptic δ-catenin levels and disrupts ultrasonic vocalization in neonates.Neuropharmacology · 2024Article
- Neurons for infant social behaviors in the mouse zona incerta.Science (New York, N.Y.) · 2024Article
- SqueakOut: Autoencoder-based segmentation of mouse ultrasonic vocalizations.bioRxiv : the preprint server for biology · 2024Article
- mRNA nuclear retention reduces AMPAR expression and promotes autistic behavior in UBE3A-overexpressing mice.EMBO reports · 2024Article
- Microglia shape AgRP neuron postnatal development via regulating perineuronal net plasticity.Molecular psychiatry · 2024Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Hypothalamic Agrp neurons regulate food ingestion in adult mice. Whether these neurons are functional before animals start to ingest food is unknown. Here, we studied the functional ontogeny of Agrp neurons during breastfeeding using postnatal day 10 mice. In contrast to adult mice, we show that isolation from the nursing nest, not milk deprivation or ingestion, activated Agrp neurons. Non-nutritive suckling and warm temperatures blunted this effect. Using in vivo fiber photometry, neonatal Agrp neurons showed a rapid increase in activity upon isolation from the nest, an effect rapidly diminished following reunion with littermates. Neonates unable to release GABA from Agrp neurons expressed blunted emission of isolation-induced ultrasonic vocalizations. Chemogenetic overactivation of these neurons further increased emission of these ultrasonic vocalizations, but not milk ingestion. We uncovered important functional properties of hypothalamic Agrp neurons during mouse development, suggesting these neurons facilitate offspring-to-caregiver bonding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.