ArticleSchizophrenia research2019
Neuropsychological functioning in early and chronic stages of schizophrenia and psychotic bipolar disorder.
Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Hippocampal subfield activity in schizophrenia: Effects of the disease course.Schizophrenia research · 2025Article
- Bipolar disorders and schizophrenia: discrete disorders?Frontiers in psychiatry · 2024Review
- Readmission and associated clinical factors among individuals admitted with bipolar affective disorder at a psychiatry facility in Uganda.BMC psychiatry · 2023Article
- Neurocognitive Deficits in First-Episode and Chronic Psychotic Disorders: A Systematic Review from 2009 to 2022.Brain sciences · 2023Review
- Reaction Time and Visual Memory in Connection to Alcohol Use in Persons with Bipolar Disorder.Brain sciences · 2021Article
- Relational memory in the early stage of psychotic bipolar disorder.Psychiatry research · 2020Article
- Mismatch Negativity and Loudness Dependence of Auditory Evoked Potentials among Patients with Major Depressive Disorder, Bipolar II Disorder, and Bipolar I Disorder.Brain sciences · 2020Article
- Brain function during stages of working memory in schizophrenia and psychotic bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Mapping cognitive trajectories across the course of illness in psychosis.Schizophrenia research · 2019Article
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5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeuropsychological impairment is common in schizophrenia and psychotic bipolar disorder. It has been hypothesized that the pathways leading to impairment differ between disorders. Cognitive impairment in schizophrenia is believed to result largely from atypical neurodevelopment, whereas bipolar disorder is increasingly conceptualized as a neuroprogressive disorder. The current investigation tested several key predictions of this hypothesis.
methodsCurrent neuropsychological functioning and estimated premorbid intellectual ability were assessed in healthy individuals (n = 260) and a large, cross-sectional sample of individuals in the early and chronic stages of psychosis (n = 410). We tested the following hypotheses: 1) cognitive impairment is more severe in schizophrenia in the early stage of psychosis; and 2) cognitive decline between early and chronic stages is relatively greater in psychotic bipolar disorder. Additionally, individuals with psychosis were classified as neuropsychologically normal, deteriorated, and compromised (i.e. below average intellectual functioning) to determine if the frequencies of neuropsychologically compromised and deteriorated patients were higher in schizophrenia and psychotic bipolar disorder, respectively.
resultsNeuropsychological impairment in the early stage of psychosis was more severe in schizophrenia. Psychotic bipolar disorder was not associated with relatively greater cognitive decline between illness stages. The frequency of neuropsychologically compromised patients was higher in schizophrenia; however, substantial portions of both schizophrenia and psychotic bipolar disorder patients were classified as neuropsychologically compromised and deteriorated.
conclusionsWhile schizophrenia is associated with relatively greater neurodevelopmental involvement, psychotic bipolar disorder and schizophrenia cannot be strictly dichotomized into purely neuroprogressive and neurodevelopmental illness trajectories; there is evidence of both processes in each disorder.
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