ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2019
[Expression and significance of Shh and Wnt5a genes in Cornelia de Lange syndrome].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo study the expression of Shh and Wnt5a genes in the limb buds of NIPBL
methodsA total of 72 NIPBL
resultsThe mRNA and protein expression of Shh and Wnt5a was detected in the limb buds on E10, E11 and E12, and the experimental group had significantly lower expression than the control group (P<0.01). The mRNA and protein expression of Shh and Wnt5a in limb buds was at a low level on E10, followed by an increase on E11 and a reduction on E12, and the expression on E12 was still lower than that on E10 (P<0.01).
conclusionsThe mRNA and protein expression of Shh and Wnt5a are consistent. The pathogenesis of CdLS may be associated with the low mRNA and protein expression of Shh and Wnt5a inhibited by the low expression of NIPBL gene.
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Identifiers
31104668PMC7389413W2950695339What OpenQuestion holds
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