ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2019
[Langerhans cell histiocytosis involving the oral and maxillofacial region: an analysis of 12 cases].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Multisystem Langerhans cell histiocytosis in a pediatric patient: a rare case report with literature review and future directions.Annals of hematology · 2025Review
- Diagnosis and treatment of isolated rib Langerhans cell histiocytosis in an adult: A case report.Frontiers in surgery · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
objectiveTo study the clinical features of Langerhans cell histiocytosis (LCH) involving the oral and maxillofacial region in children.
methodsA retrospective analysis was performed for the clinical data of 12 children with LCH involving the oral and maxillofacial region who were hospitalized and treated from September 2012 to September 2017, including clinical manifestations, pathological features, treatment and prognosis.
resultsOf the 12 children, 8 (67%) had multiple system involvement and 7 (58%) had the involvement of organs at risk. Bone was the most common affected site (11 children, 92%), among whom 7 children had the involvement of the mandible. Oral soft tissue involvement manifested as gingival ulcer or hyperplasia in 4 children, loose teeth in 5 children, oral mucosal lesions in 2 children, and nodular lesions in 1 child. Pathological examination showed positive CDla in 11 children and positive CD207, CD68, S-100, and LCA in 12 children. Surgery combined with chemotherapy was the major treatment method, and surgical resection alone was performed for focal lesions. After treatment, 11 children were cured or improved and 1 gave up treatment and was lost to follow-up. No recurrence was observed.
conclusionsLCH children with oral and maxillofacial involvement often have the involvement of multiple systems and organs at risk, with the mandible as the most common affected site. These children may also have the involvement of gingiva, oral mucosa and teeth. Surgery combined with chemotherapy is the major treatment method, and the patients generally have a good prognosis without recurrence.
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31104654PMC7389420W3025951301What OpenQuestion holds
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