Evidence map›Paper›PMID 31104419›Full record

ArticleIranian biomedical journal2019

Alu DNA Polymorphism of Human Tissue Plasminogen Activator (tPA) Gene in Diabetic Jordanian Patients

Salem R. Yasin, Hussam H. AlHawari, Abeer A. Alassaf, Maysa M. Khadra, Zainab A. Al-Mazaydeh, Ala'a F. Al-Emerieen, Lubna H. Tahtamouni

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In one paragraph

Article in Iranian biomedical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Salem R. YasinDepartment of Biology and Biotechnology, Faculty of Science, the Hashemite University, Zarqa, Jordan.
Hussam H. AlHawariDepartment of Internal Medicine, Faculty of Medicine, University of Jordan, Amman, Jordan.
Abeer A. AlassafDepartment of Pediatric, Faculty of Medicine, University of Jordan, Amman, Jordan.
Maysa M. KhadraDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Jordan, Amman, Jordan.
Zainab A. Al-MazaydehDepartment of Biology and Biotechnology, Faculty of Science, the Hashemite University, Zarqa, Jordan.
Ala'a F. Al-EmerieenDepartment of Service Courses, Faculty of Science, Zarqa Private University, Zarqa, Jordan.
Lubna H. TahtamouniDepartment of Biology and Biotechnology, Faculty of Science, the Hashemite University, Zarqa, Jordan.
Hashemite University · JOUniversity of Jordan · JOZarqa University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypercoagulability and hypofibrinolysis are among the symptoms exhibited by diabetic patients. Our study aimed to address the polymorphic nature of Alu DNA fragment in the human tissue plasminogen activator gene within diabetes mellitus (DM) Jordanian patients. Methods: Genomic DNA was isolated from 76 DM patients and 60 non-diabetic Jordanian individuals, and the Alu fragment was amplified using PCR. Results: The results showed that 80% of the non-diabetic Jordanian subjects were homozygotes for the deletion of the Alu fragment (Alu-/-), 16.7% were homozygotes for its insertion (Alu+/+), and 3.3% were heterozygotes (Alu+/-). Besides, 36.8% of the diabetic patients exhibited the Alu-/- or Alu+/- genotype, and 26.3% were Alu+/+. The Alu-/- genotype occurred less frequently in the diabetic individuals. Conclusion: The high frequency of the Alu-/- genotype constitutes a protective deletion with respect to DM within the normal subjects.

Indexed as

Polymorphism, GeneticAllelesAlu ElementsDiabetes MellitusGene FrequencyHumansJordanTissue Plasminogen ActivatorTissue Plasminogen ActivatorAluDiabetes mellitusPolymorphism

Identifiers

PMID31104419
PMCPMC6800539
OpenAlexW2978529241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.