SynthesisCancer medicine2019
Increased risk of pelvic fracture after radiotherapy in rectal cancer survivors: A propensity matched study.
Synthesis in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Increased risk of pelvic fracture after radiotherapy in rectal cancer survivors: A propensity matched study.Cancer medicine · 2019Pooled it
- Late effects among colorectal cancer survivors ≥5 years after diagnosis-a systematic scoping review.JNCI cancer spectrum · 2026Article
- Computed Tomography Attenuation of Bone Predicts Incident Fracture in Patients With Anorectal Cancer Treated With Radiation.Advances in radiation oncology · 2026Article
- Estimation of bone mineral density with computed tomography performed in radiotherapy planning.Physics and imaging in radiation oncology · 2026Article
- Japanese cancer survivors have a higher risk of fragility fractures over ten years.Scientific reports · 2026Article
- Detection of vertebral insufficiency fractures onRadiology case reports · 2025Article
- Interventional Radiology Management of Bone Metastasis Pain: Strategies and Techniques.Cardiovascular and interventional radiology · 2025Review
- Review
- Case report: Chest radiotherapy-induced vertebral fractures in lung cancer patients: a case series and literature review.Frontiers in oncology · 2025Article
- Patient-reported outcomes after treatment for rectal cancer-A prospective nationwide study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2024Article
- Unveiling the profound advantages of total neoadjuvant therapy in rectal cancer: a trailblazing exploration.Annals of surgical treatment and research · 2023Review
- Multi-Disciplinary Management in Rectal Cancer Survivorship: A Clinical Practice Review.Journal of gastrointestinal cancer · 2023Review
- Short-course preoperative radiotherapy increases pelvic fracture risk in rectal cancer.Clinical and translational radiation oncology · 2023Article
- Relative Effects of Radiation-Induced Changes in Bone Mass, Structure, and Tissue Material on Vertebral Strength in a Rat Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Radiotherapy-related insufficiency fractures and bone mineral density: what is the connection?Endocrine connections · 2023Article
- Fracture Risk Among Older Cancer Survivors Compared With Older Adults Without a History of Cancer.JAMA oncology · 2023Article
- Persistent Abnormal Immunocytes Induced Systemic Bone Loss in Locally Irradiated Rats.Calcified tissue international · 2021Article
- Relations Between Bone Quantity, Microarchitecture, and Collagen Cross-links on Mechanics Following In Vivo Irradiation in Mice.JBMR plus · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine whether radiotherapy (RT) can increase pelvic fracture risk in rectal cancer survivors. Rectal cancer patients who underwent curative surgery between 1996 and 2011 in Taiwan were retrospectively studied using the National Health Insurance Research Database (NHIRD) of Taiwan. ICD-9 Codes 808, 805.4-805.7, 806.4-806.7, and 820 (including pelvic, sacrum, lumbar, and femoral neck fracture) were defined as pelvic fracture. Propensity scores for RT, age, and sex were used to perform one-to-one matches between the RT and non-RT group. Risks of pelvic and arm fractures were compared by multivariable Cox regression. Of the 32 689 patients, 7807 (23.9%) received RT, and 1616 suffered from a pelvic fracture (incidence rate: 1.17/100 person-years). The median time to pelvic fracture was 2.47 years. After matching, 6952 patients each in the RT and non-RT groups were analyzed. RT was associated with an increased risk of pelvic fractures in the multivariable Cox model (hazard ratio (HR): 1.246, 95% confidence interval (CI): 1.037-1.495, P = 0.019) but not with arm fractures (HR: 1.013, 95% CI: 0.814-1.259, P = 0.911). Subgroup analyses revealed that RT was associated with a higher pelvic fracture rate in women (HR: 1.431, 95% CI: 1.117-1.834) but not in men, and the interaction between sex and RT was significant (P = 0.03). The HR of pelvic fracture increased 2-4 years after RT (HR: 1.707, 95% CI: 1.150-2.534, P = 0.008). An increased risk of pelvic fracture is noted in rectal cancer survivors, especially women, who receive RT.
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