Evidence map›Paper›PMID 31104359›Full record

ArticleThoracic cancer2019

Prognostic value of a novel scoring system using inflammatory response biomarkers in non-small cell lung cancer: A retrospective study.

Yan Wang, Xu Hu, Wenying Xu, Haoyuan Wang, Yu Huang, Guowei Che

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yan WangDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-8622-3480
Xu HuWest China School of Medicine, Sichuan University, Chengdu, China.
Wenying XuWest China School of Medicine, Sichuan University, Chengdu, China.
Haoyuan WangWest China School of Medicine, Sichuan University, Chengdu, China.
Yu HuangWest China School of Medicine, Sichuan University, Chengdu, China.
Guowei CheDepartment of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0003-2187-6346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are reported to show a strong correlation with prognosis in patients with non-small cell lung cancer (NSCLC). We aimed to describe a novel scoring system combining these ratios, termed the inflammatory response biomarker (IRB) score, and test its prognostic value in NSCLC.

methodsThe data of 261 NSCLC patients who underwent thoracoscopic radical resection in a single center were retrospectively reviewed. The IRB score was defined as follows: a high NLR (> 2.12), a high PLR (92.9), and a low LMR (< 4.57) were each scored as 1; the opposite values were scored as 0. The individual scores were added to produce the IRB score (range: 0-3).

resultsMultivariate analyses indicated that high tumor node metastasis (TNM) stage (hazard ratio [HR] 2.721, 95% confidence interval [CI] 1.597-4.989; P < 0.001) and an IRB score ≥ 2 (HR 2.696, 95% CI 1.506-4.826; P = 0.001) were independent prognostic factors for poor overall survival. Furthermore, smoking history (HR 2.953, 95% CI 1.086-8.026; P = 0.034), high TNM stage (HR 3.108, 95% CI 1.911-5.056; P < 0.001), and IRB score ≥ 2 (HR = 2.316, 95% CI: 1.389-3.861; P = 0.001) were demonstrated to be independent prognostic factors for poor disease-free survival.

conclusionThe novel scoring system combining NLR, PLR, and LMR was an independent prognostic factor in NSCLC patients undergoing thoracoscopic radical resection and was superior to these ratios alone for predicting prognosis.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorBlood Cell CountCarcinoma, Non-Small-Cell LungFemaleHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisNeoplasm StagingPneumonectomyPrognosisBiomarkers, TumorInflammatory response biomarker scorelymphocyte-to-monocyte rationeutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratio; non-small cell lung cancer

Identifiers

PMID31104359
PMCPMC6558461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.