Evidence map›Paper›PMID 31104354›Full record

ArticleJournal of cellular and molecular medicine2019

Cardiac-specific overexpression of metallothionein attenuates L-NAME-induced myocardial contractile anomalies and apoptosis.

Lifang Yang, Jipeng Ma, Ying Tan, Qijun Zheng, Maolong Dong, Wei Guo, Lize Xiong, Jian Yang, Jun Ren

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  7. [Effects and cell signaling mechanism of glutamine on rat cardiomyocytes intervened with serum from burned rat].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Lifang YangDepartment of Anesthesiology, Xi'an Children Hospital, Xi'an, China.
Jipeng MaCenter for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming.
Ying TanCenter for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming.
Qijun ZhengDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Maolong DongCenter for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming.
Wei GuoDepartment of Animal Sciences, University of Wyoming, Laramie, Wyoming.
Lize XiongDepartment of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jian YangDepartment of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Jun RenCenter for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming.ORCID 0000-0002-0275-0783
University of Wyoming · USXijing Hospital · CN

Funding

Wyoming INBRE Phase 4- Equipment Supplement for x-ray diffractometer for Center for Advanced Scientific InstrumentationP20GM103432 · NIGMS · UNIVERSITY OF WYOMING · PI Robert Scott Seville · 2012 to 2026
$56.8M
NIGMS NIH HHS P20 GM103432
6 · The paper itself

Abstract

Hypertension contributes to the high cardiac morbidity and mortality. Although oxidative stress plays an essential role in hypertensive heart diseases, the mechanism remains elusive. Transgenic mice with cardiac overexpression of metallothionein, a heavy metal-binding scavenger, were challenged with N

Indexed as

AnimalsApoptosisBiomarkersBlood PressureCalciumElectrocardiographyInflammationMembrane Potential, MitochondrialMetallothioneinMice, TransgenicMitochondriaMyocardial ContractionMyocardiumNG-Nitroarginine Methyl EsterOrgan SpecificitySuperoxidesBiomarkersCalciumMetallothioneinNG-Nitroarginine Methyl EsterSuperoxidesapoptosishearthypertensionL-NAMEmetallothionein

Identifiers

PMID31104354
PMCPMC6584723
OpenAlexW2945709695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.