Evidence map›Paper›PMID 31104291›Full record

ArticleJournal of assisted reproduction and genetics2019

Reproductive success of assisted reproductive technology in couples with chromosomal abnormalities.

Ana Rita Jesus, Sandra Silva-Soares, Joaquina Silva, Milton Severo, Alberto Barros, Sofia Dória

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Current opportunities and new horizons into the genetic study of infertility.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ana Rita JesusGenetics Department, Faculty of Medicine (FMUP), University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Sandra Silva-SoaresUnidade de Medicina da Reprodução, Centro Hospitalar Universitário São João (CHUSJ), Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Joaquina SilvaCentro de Genética e Reprodução Professor Alberto Barros, Avenida do Bessa, 4100-012, Porto, Portugal.
Milton SeveroEPIUnit - Institute of Public Health, University of Porto, Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Alberto BarrosGenetics Department, Faculty of Medicine (FMUP), University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.
Sofia DóriaGenetics Department, Faculty of Medicine (FMUP), University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal. sdoria@med.up.pt.ORCID http://orcid.org/0000-0001-9225-9076
Universidade do Porto · PTCentro de Genética Clínica · PTHospital de São João · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInfertility is estimated to affect 15% of couples, having chromosome abnormalities an important role in its etiology. The main objective of this work was to access the reproductive success of ART in infertile couples with chromosomal abnormalities comparing to a control group with normal karyotype.

methodsA 7-year retrospective karyotype analysis of infertile couples was done. Data regarding type of infertility, couples' ages, ART performed, and their reproductive success were obtained. Adjusted odds ratio (OR) were used to estimate magnitude of association between the reproductive success and the different groups.

resultsWe found a prevalence of 7.83% of chromosome abnormalities in our population (233 couples out of 2989). Chromosomal anomalies were found in 82 men (34.75%) and 154 women (65.25%), with low-grade mosaicism being the most prevalent (50.85%), followed by autosomal translocations (17.37%) and sex chromosomes abnormalities (13.56%). Only 2359 couples were treated with ART. There was a non-significant lower reproductive success rate in the cases (OR = 0.899, p = 0.530) with IVF providing the higher success rate. In general, female carriers of chromosome anomalies had a higher success rate, although not significant.

conclusionAlthough the differences regarding success rate between groups were not found statistically significant, we still advocate that cytogenetic analysis should be performed routinely in all infertile couples namely before ART. This might help deciding the best treatment options including Preimplantation Genetic Testing for aneuploidies or structural rearrangements and minimize the risk of transmission of anomalies to the offspring.

Indexed as

Chromosome AberrationsReproductive Techniques, AssistedAdultAneuploidyChromosome DisordersFemaleFertilization in VitroGenetic TestingHumansInfertility, MaleKaryotypingMalePregnancyPregnancy OutcomeSperm Injections, IntracytoplasmicAssisted reproduction technologyChromosome abnormalitiesInfertilityKaryotype

Identifiers

PMID31104291
PMCPMC6642249
OpenAlexW2945441491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.