ArticleClinical and experimental nephrology2019
E-cadherin and periostin in early detection and progression of diabetic nephropathy: epithelial-to-mesenchymal transition.
Article in Clinical and experimental nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Meta-Analysis and Bioinformatics Detection of Susceptibility Genes in Diabetic Nephropathy.International journal of molecular sciences · 2021Pooled it
- Exploratory insights into salivary E-cadherin as a non-invasive biomarker in a rat model of diabetes.Scientific reports · 2025Article
- Role of serum periostin level as profibrotic marker in conjunction with renal resistivity index and shear wave elastography in predicting renal fibrosis in diabetic nephropathy.BMC nephrology · 2025Article
- Crosstalk of Hyperglycaemia and Cellular Mechanisms in the Pathogenesis of Diabetic Kidney Disease.International journal of molecular sciences · 2024Review
- Therapeutic Effect of Desmodium caudatum Extracts on Alleviating Diabetic Nephropathy Mice.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Article
- Article
- Review
- Review of potential biomarkers of inflammation and kidney injury in diabetic kidney disease.Diabetes/metabolism research and reviews · 2022Review
- Re-understanding and focusing on normoalbuminuric diabetic kidney disease.Frontiers in endocrinology · 2022Review
- Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy.Frontiers in endocrinology · 2022Article
- Identification of Hub Genes Involved in Tubulointerstitial Injury in Diabetic Nephropathy by Bioinformatics Analysis and Experiment Verification.Journal of immunology research · 2022Article
- Plasma periostin as a biomarker of osteoporosis in postmenopausal women with type 2 diabetes.Journal of bone and mineral metabolism · 2021Article
- Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension.Journal of clinical medicine · 2021Article
- Review on Inflammation Markers in Chronic Kidney Disease.Biomedicines · 2021Review
- Article
- Advances in the Progression and Prognosis Biomarkers of Chronic Kidney Disease.Frontiers in pharmacology · 2021Review
- The role of periostin in kidney diseases.Central-European journal of immunology · 2021Review
- Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.Journal of cellular and molecular medicine · 2020Article
- Early detection of diabetic nephropathy in patient with type 2 diabetes mellitus: A review of the literature.Diabetes & vascular disease researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Many mechanisms are involved in its development; one of these mechanisms is epithelial-to-mesenchymal transition (EMT). During EMT, losing of the epithelial biomarkers like E-cadherin and increasing of mesenchymal biomarkers like periostin are very characteristic.
methodsThe study included 19 healthy controls and 71 DN patients categorized according to their urinary albumin-to-creatinine ratio (UACR) into 19 normoalbuminuric (UACR < 30 mg/g), 37 microalbuminuric (UACR 30-300 mg/g), and 15 macroalbuminuric (UACR > 300 mg/g) patients. Fasting plasma glucose (FPG), glycated hemoglobin (HbA
resultsConcerning E-cadherin levels, in comparison to control group, there were significantly decreased in all groups (0.94, 0.52, and 0.14 ng/mL in normoalbuminuria, microalbuminuria, and macroalbuminuria groups; respectively). For periostin levels, nonsignificant increase in normoalbuminuria (0.32 ng/mL) than control group (0.3 ng/mL) was observed. There was a significant increase in other groups with the highest values in macroalbuminuria group (1.66 ng/mL). E-cadherin and periostin were correlated with each other (r = - 0.353, P < 0.001). UACR was negatively correlated with E-cadherin and positively correlated with periostin. ROC curve analyses showed that the AUC to diagnose established microalbuminuria using E-cadherin was 0.998 (95% CI 0. 932-1), and using periostin was 0.833 (95% CI 0.709-0.919).
conclusionSerum E-cadherin and periostin could be considered as reliable biomarkers involved in DN pathogenesis and linked to its stages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.