Evidence map›Paper›PMID 31104250›Full record

ArticleFish physiology and biochemistry2019

Three forms of cocaine- and amphetamine-regulated transcript may be involved in food intake regulation in gibel carp (Carassius auratus gibelio).

Chaowei Zhou, Luo Lei, Xingxing Deng, Dengyue Yuan, Chengke Zhu, Hua Ye, Hui Luo, Chi Zhang, Jianshe Zhou, Minmin Yang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Fish physiology and biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Chaowei ZhouDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Luo LeiDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Xingxing DengDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Dengyue YuanDepartment of Aquaculture, College of Life Sciences, Neijiang Normal University, Neijiang, 641000, Sichuan, People's Republic of China.
Chengke ZhuDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Hua YeDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Hui LuoDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Chi ZhangTibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, 850002, Tibet, People's Republic of China.
Jianshe ZhouTibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, 850002, Tibet, People's Republic of China.
Minmin YangDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Jian WangDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China.
Benhe ZengTibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, 850002, Tibet, People's Republic of China.
Baohai LiTibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, 850002, Tibet, People's Republic of China. lbh0891@163.com.
Zonglin ZhengDepartment of Aquaculture, College of Animal Science, Southwest University, Chongqing, 402460, People's Republic of China. zhengzonglin@126.com.
Southwest University · CNTibet Academy of Agricultural and Animal Husbandry Sciences · CNNeijiang Normal University · CN

Funding

Fundamental Research Funds for the Central Universities No. XDJK2018C053
6 · The paper itself

Abstract

In fish, as in mammals, several studies have demonstrated that the cocaine- and amphetamine-regulated transcript (CART) plays an important role in feeding. However, thus far, the function of CART in gibel carp (Carassius auratus gibelio) feeding regulation has not been reported. In our study, we first identified three forms of CART peptide precursors from gibel carp brain and named these CART-1, CART-2, and CART-3. The full-length cDNA sequences of CART-1, CART-2, and CART-3 were 616 bp, 705 bp, and 760 bp, respectively, encoding peptides of 118, 120, and 104 amino acid residues. We detected mRNA expression of CART-1, CART-2, and CART-3 in a wide range of peripheral and central tissues, with the highest expression detected in the brain. After a meal, mRNA expression of CART-1, CART-2, and CART-3 was significantly elevated, suggesting that CART-1, CART-2, and CART-3 may act as postprandial satiety signals. Moreover, mRNA expression of all three CART-1, CART-2, and CART-3 was significantly reduced during fasting and significantly elevated with refeeding. Our findings indicate that CART-1, CART-2, and CART-3 might function as a satiety factor in the gibel carp.

Indexed as

Amino Acid SequenceAnimalsBase SequenceCloning, MolecularCocaine- and Amphetamine-Regulated Transcript ProteinFeeding BehaviorFish ProteinsGene Expression RegulationGoldfishNerve Tissue ProteinsPhylogenyProtein IsoformsCocaine- and Amphetamine-Regulated Transcript ProteinFish ProteinsNerve Tissue ProteinsProtein IsoformsCloningCocaine- and amphetamine-regulated transcriptFastingFeedingGibel carp

Identifiers

PMID31104250
OpenAlexW2945144341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.