ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2019
Complex regional pain syndrome: a focus on the autonomic nervous system.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07446712 (Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome), which is not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hyperbaric Oxygen Therapy in Complex Regional Pain Syndrome: a Randomised Controlled Trial
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Effects of mobilization or manipulation of the thoracic spine on autonomic nervous system markers in symptomatic and asymptomatic participants - a systematic review and meta-analysis.The Journal of manual & manipulative therapy · 2025Pooled it
- Interventions for treating pain and disability in adults with complex regional pain syndrome- an overview of systematic reviews.The Cochrane database of systematic reviews · 2023Pooled it
- Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.The Cochrane database of systematic reviews · 2022Pooled it
- Automatic quantification of thermographic images of complex regional pain syndrome using radiomics and deep learning.Pain reports · 2026Article
- Patients' Experiences With Complex Regional Pain Syndrome (CRPS) and a Rehabilitation Program That Combines Graded Motor Imagery (GMI) and Tactile Desensitization (TD).Pain research & management · 2026Article
- Diagnostic Criteria and Technical Evaluation of Complex Regional Pain Syndrome: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Comparative Analysis of Temperature Variations Following Sympathetic Blocks in Warm and Cold Subtypes of Complex Regional Pain Syndrome (CRPS): A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Weathering the Pain: Ambient Temperature's Role in Chronic Pain Syndromes.Current pain and headache reports · 2025Review
- Comprehensive Mechanisms and Non-Invasive Treatment for Complex Regional Pain Syndrome: A Narrative Review.Journal of pain research · 2025Review
- Additional evidence from a case report supports a novel hypothesis on the association between complex regional pain syndrome and lymphedema.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Spinal cord stimulation for the treatment of complex regional pain syndrome: A systematic review of randomized controlled trials.Interventional pain medicine · 2024Review
- A brief review of complex regional pain syndrome and current management.Annals of medicine · 2024Review
- Benign Evolution of Complex Regional Pain Syndrome (CRPS) Type 1 in Patients Treated with Intravenous Neridronate: A Single-Center Real-Life Experience.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Effect duration of lumbar sympathetic ganglion neurolysis in patients with complex regional pain syndrome: a prospective observational study.Scientific reports · 2024Observational
- Lumbar Sympathetic Block Leading to Increased Arterial Diameter and Blood Flow: A Mechanism of Therapeutic Benefit.Cureus · 2024Article
- Article
- Mechanisms of complex regional pain syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- The Effectiveness of Hyperbaric Oxygen Treatment in Patients with Complex Regional Pain Syndrome: A Retrospective Case series.International journal of medical sciences · 2024Article
- Peripheral BDNF Regulates Somatosensory-Sympathetic Coupling in Brachial Plexus Avulsion-Induced Neuropathic Pain.Neuroscience bulletin · 2023Article
- The complex regional pain syndrome: Diagnosis and management strategies.Neurosciences (Riyadh, Saudi Arabia) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough autonomic features are part of the diagnostic criteria for complex regional pain syndrome (CRPS), the role of the autonomic nervous system in CRPS pathophysiology has been downplayed in recent years. The purpose of this review is to redress this imbalance.
methodsWe focus in this review on the contribution of the autonomic nervous system to CRPS pathophysiology. In particular, we discuss regional sympathetic and systemic autonomic disturbances in CRPS and the mechanisms which may underlie them, and consider links between these mechanisms, immune disturbances and pain.
resultsThe focused literature research revealed that immune reactions, alterations in receptor populations (e.g., upregulation of adrenoceptors and reduced cutaneous nerve fiber density) and central changes in autonomic drive seem to contribute to regional and systemic disturbances in sympathetic activity and to sympathetically maintained pain in CRPS.
conclusionsWe conclude that alterations in the sympathetic nervous system contribute to CRPS pathology. Understanding these alterations may be an important step towards providing appropriate treatments for CRPS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.