Evidence map›Paper›PMID 31104019›Full record

ArticleJournal of Alzheimer's disease : JAD2019

Mild Cognitive Impairment and Decline in Resting State Functional Connectivity after Total Knee Arthroplasty with General Anesthesia.

Cheshire Hardcastle, Hua Huang, Sam Crowley, Jared Tanner, Carlos Hernaiz, Mark Rice, Hari Parvataneni, Mingzhou Ding, Catherine C Price

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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  5. The New Frontier of Perioperative Cognitive Medicine for Alzheimer's Disease and Related Dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Cheshire HardcastleDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Hua HuangJ Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Sam CrowleyDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Jared TannerDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Carlos HernaizDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Mark RiceDivision of Multispecialty Adult Anesthesiology, Vanderbilt University, Gainesville, FL, USA.
Hari ParvataneniDepartment of Orthopedic Surgery, University of Florida, Gainesville, FL, USA.
Mingzhou DingJ Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Catherine C PriceJ Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
University of Florida · USUniversity of Florida Health · USVanderbilt University · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Together: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5M
Together: Transforming and Translating Discovery to Improve HealthTL1TR001428 · NCATS · UNIVERSITY OF FLORIDA · PI MCCORMACK, WAYNE T. · 2015 to 2023
$3.9M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
Neuroimaging Biomarkers for Post-Operative Cognitive Decline in Older AdultsR01NR014181 · NINR · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2012 to 2016
$2.3M
NCATS NIH HHS KL2 TR001429NCATS NIH HHS TL1 TR001428NCATS NIH HHS UL1 TR001427NINDS NIH HHS L30 NS071590NINDS NIH HHS T32 NS082168NINR NIH HHS R01 NR014181
6 · The paper itself

Abstract

backgroundResearch shows that older adults can have a decline in three key resting state networks (default mode network, central executive network, and salience network) after total knee arthroplasty and that patients' pre-surgery brain and cognitive integrity predicts decline.

objectivesFirst, to assess resting state network connectivity decline from the perspective of nodal connectivity changes in a larger older adult surgery sample. Second, to compare pre-post functional connectivity changes in mild cognitive impairment (MCI) versus non-MCI.

methodsSurgery (n = 69) and non-surgery (n = 65) peers completed a comprehensive preoperative neuropsychological evaluation and pre- and acute (within 48 hours) post-surgery/pseudo-surgery functional brain magnetic resonance imaging scan. MCI was classified within both (MCI surgery, n = 13; MCI non-surgery, n = 10). Using standard coordinates, we defined default mode network, salience network, central executive network, and the visual network (serving as a control network). The functional connectivity of these networks and brain areas (nodes) that make up these networks were examined for pre-post-surgery changes through paired samples t-test and ANOVA.

resultsThere was a decline in RSN connectivity after surgery (p < 0.05) only in the three cognitive networks (not the visual network). The default mode and salience network showed nodal connectivity changes (p < 0.01). MCI surgery had greater functional connectivity decline in DMN and SN. Non-surgery participants showed no significant functional connectivity change.

conclusionSurgery with general anesthesia selectively alters functional connectivity in major cognitive resting state networks particularly in DMN and SN. Participants with MCI appear more vulnerable to these functional changes.

Indexed as

AgedAged, 80 and overAnesthesia, GeneralArthroplasty, Replacement, KneeBrainCase-Control StudiesCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuroimagingAnesthesiacognitive dysfunctiondementiafunctional magnetic resonance imagingmild cognitive impairmentorthopedicssurgery

Identifiers

PMID31104019
PMCPMC6629260
OpenAlexW2944875846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.