ArticleJournal of neurointerventional surgery2019
Intrathrombus polymer coating deposition: a pilot study of 91 patients undergoing endovascular therapy for acute large vessel stroke. Part I: Histologic frequency.
Article in Journal of neurointerventional surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cerebral Foreign Body Granulomatous Reaction Secondary to Hydrophilic Polymer Embolization Post-Mechanical Thrombectomy: A Case Report and Overview of Differential Diagnosis.Stroke (Hoboken, N.J.) · 2026Article
- Damage to Polymer Coatings on Microguidewire Tips through Shaping and J-wiring for Optimizing Flow Diverter Deployment: A Scanning Electron Microscopy Study.Neurointervention · 2026Article
- Hydrophilic Polymer Embolism: An Underappreciated Complication of Endovascular Procedures that Physicians Should be Aware Of.Cardiovascular and interventional radiology · 2025Review
- Fragmentation of Hydrophilic Guidewire Coatings During Neuroendovascular Therapy.Clinical neuroradiology · 2023Article
- Non-ischemic cerebral enhancing lesions after thrombectomy: a multicentric retrospective French national registry.Neuroradiology · 2022Article
- Polytetrafluoroethylene coating fragments during neuroendovascular therapy: An analysis of two damaged microguidewires.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022Article
- Clot Composition Analysis as a Diagnostic Tool to Gain Insight into Ischemic Stroke Etiology: A Systematic Review.Journal of stroke · 2021Review
- Delayed leukoencephalopathy from suspected polymer embolism after neuroendovascular procedures.The neuroradiology journal · 2021Review
- Iatrogenic Foreign Materials Associated with Retrieved Clot Tissue via Mechanical Thrombectomy.AJNR. American journal of neuroradiology · 2021Article
- Delayed Leukoencephalopathy: A Rare Complication after Coiling of Cerebral Aneurysms.AJNR. American journal of neuroradiology · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundPolymer coating embolism due to vascular medical device use is an increasingly recognized iatrogenic complication. This phenomenon has been linked with various adverse effects including neuroinflammation, acute ischemic stroke, cerebral hemorrhage, and death. Notably, procedure- and device-specific risks of this complication are poorly investigated. In this study, we evaluate the detectable frequency of intra-arterial polymer coating delamination among patients who underwent endovascular thrombectomy for treatment of acute ischemic stroke due to large vessel occlusion.
methodsNinety-two cerebral thrombectomy specimens were retrospectively analyzed for the presence of polymer coating particulates. Histologic findings were correlated with demographic and procedural details and patient outcomes.
resultsEvidence of polymer coating deposition was found in 30 of 92 extracted thrombi (33%). No correlation between intrathrombus polymer deposition and use of a specific thrombectomy device such as a stent retriever, aspiration catheter, or guide catheter was found. However, heterogeneous patterns of device use suggest a number of culprit devices. A trend toward longer procedure times and multiple thrombectomy passes was noted in positive cases. Intrathrombus polymer deposition was not associated with adverse clinical outcomes as measured by the 90-day modified Rankin Scale (mRS); however, small sample size and follow-up intervals limit interpretation. Ninety-day outcomes based on mRS may not fully capture the clinical effects of acute and/or delayed intracerebral polymer complications.
conclusionIn light of documented adverse neurologic effects, the frequency of intrathrombus polymer particulates indicates the need for consensus testing methods and large-scale long-term prospective clinical device trials, with inclusion of relevant endpoints to better assess biomaterial and device risks to patients.
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