ArticleEnvironmental research2019
Myo-inositol mediates the effects of traffic-related air pollution on generalized anxiety symptoms at age 12 years.
Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of air pollution exposure and brain structure and function during development.Environmental research · 2025Pooled it
- Toxicant exposure and the developing brain: A systematic review of the structural and functional MRI literature.Neuroscience and biobehavioral reviews · 2023Pooled it
- Air pollution, depressive and anxiety disorders, and brain effects: A systematic review.Neurotoxicology · 2022Pooled it
- A review of indoor air quality interventions and child neurobehavioral outcomes.Pediatric research · 2026Review
- Review
- Fronto-striatal neurometabolite signatures of impulsivity in early abstinence from methamphetamine.NeuroImage. Clinical · 2026Article
- Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence.Biological psychiatry global open science · 2025Article
- A Systematic Review of Air Pollution Exposure and Brain Structure and Function during Development.medRxiv : the preprint server for health sciences · 2024Article
- Outdoor air pollution and brain development in childhood and adolescence.Trends in neurosciences · 2024Review
- Air pollution and age-dependent changes in emotional behavior across early adolescence in the U.S.Environmental research · 2024Article
- Environmental Toxicants and the Developing Brain.Biological psychiatry · 2023Review
- Early-Life Exposure to Traffic-Related Air Pollutants Induced Anxiety-like Behaviors in Rats via Neurotransmitters and Neurotrophic Factors.International journal of molecular sciences · 2022Article
- Early exposure to flame retardants is prospectively associated with anxiety symptoms in adolescents: A prospective birth cohort study.Depression and anxiety · 2022Article
- Neurotoxicants, the Developing Brain, and Mental Health.Biological psychiatry global open science · 2022Article
- Mental and Physical Stress Responses to Personal Ultrafine Particle Exposure in Adolescents.International journal of environmental research and public health · 2022Article
- Pediatric Exposures to Neurotoxicants: A Review of Magnetic Resonance Imaging and Spectroscopy Findings.Diagnostics (Basel, Switzerland) · 2022Review
- Novel Chemical and Biological Insights of Inositol Derivatives in Mediterranean Plants.Molecules (Basel, Switzerland) · 2022Review
- Impact of ambient air pollution on outdoor employees' performance: Mediating role of anxiety.Frontiers in psychology · 2022Article
- Association of Outdoor Ambient Fine Particulate Matter With Intracellular White Matter Microstructural Properties Among Children.JAMA network open · 2021Article
- Adolescent Brain Cognitive Development (ABCD) study Linked External Data (LED): Protocol and practices for geocoding and assignment of environmental data.Developmental cognitive neuroscience · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundExposure to traffic-related air pollution (TRAP) has been linked to childhood anxiety symptoms. Neuroimaging in patients with anxiety disorders indicate altered neurochemistry.
objectivesEvaluate the impact of TRAP on brain metabolism and its relation to childhood anxiety symptoms in the Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS).
methodsAdolescents (n = 145) underwent magnetic resonance spectroscopy. Brain metabolites, including myo-inositol, N-acetylaspartate, creatine, choline, glutamate, glutamate plus glutamine, and glutathione were measured in the anterior cingulate cortex. Anxiety symptoms were assessed using the Spence Children's Anxiety Scale. TRAP exposure in early-life, averaged over childhood, and during the 12 months prior to imaging was estimated using a validated land use regression model. Associations between TRAP exposure, brain metabolism, and anxiety symptoms were estimated using linear regression and a bootstrapping approach for testing mediation by brain metabolite levels.
resultsRecent exposure to high levels of TRAP was associated with significant increases in myo-inositol (β = 0.26; 95%CI 0.01, 0.51) compared to low TRAP exposure. Recent elevated TRAP exposure (β = 4.71; 95% CI 0.95, 8.45) and increased myo-inositol levels (β = 2.98; 95% CI 0.43, 5.52) were also significantly associated with increased generalized anxiety symptoms with 12% of the total effect between TRAP and generalized anxiety symptoms being mediated by myo-inositol levels.
conclusionsThis is the first study of children to utilize neuroimaging to link TRAP exposure, metabolite dysregulation in the brain, and generalized anxiety symptoms among otherwise healthy children. TRAP may elicit atypical excitatory neurotransmission and glial inflammatory responses leading to increased metabolite levels and subsequent anxiety symptoms.
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