ReviewJournal of molecular biology2019
The Structure of Dental Plaque Microbial Communities in the Transition from Health to Dental Caries and Periodontal Disease.
Review in Journal of molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
210 citing papers in PubMed, 5 syntheses or guidelines pooled it, 384 citations in OpenAlex.
- Ozonated water as a preventive oral hygiene aid: a systematic review and meta-analysis of its role in reducing dental plaque.Evidence-based dentistry · 2026Pooled it
- Oral mucosal microbiome alterations in recurrent aphthous stomatitis: a systematic review of 16 S rRNA gene sequencing studies.Molecular biology reports · 2026Pooled it
- Activity and levels of TNF-α, IL-6 and IL-8 in saliva of children and young adults with dental caries: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Prevalence of early childhood caries in South Africa: a systematic review.BMC oral health · 2022Pooled it
- A Systematic Review and Meta-Analysis of the Role of Sugar-Free Chewing Gum on Plaque Quantity in the Oral Cavity.Frontiers in oral health · 2022Pooled it
- Effect of intensive application of self-assembling peptide P11-4 with fluoride, casein phosphopeptide amorphous calcium phosphate fluoride and sodium fluoride on streptococcus mutans level in preschool children: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Efficacy of toothpaste containing OPTIMEALTH® OR in inhibiting dental plaque and gingivitis: A randomized controlled trial.Medicine · 2025Trial
- Quantitative analysis of the effects of brushing, flossing, and mouthrinsing on supragingival and subgingival plaque microbiota: 12-week clinical trial.BMC oral health · 2024Trial
- Efficacy of a mouthwash containing ε-poly-L-lysine, funme peptides and domiphen in reducing halitosis and supragingival plaque: a randomized clinical trial.BMC oral health · 2024Trial
- Comparative efficacy of topical povidone-iodine and chlorhexidine gel on dental plaque regrowth in toddlers: A randomized controlled trial.Clinical and experimental dental research · 2023Trial
- Effect of a multichannel oral irrigator on periodontal health and the oral microbiome.Scientific reports · 2023Trial
- Child saliva microbiota and caries: a randomized controlled maternal education trial in rural Uganda.Scientific reports · 2022Trial
- Therapeutic Potential of Cannabidiol in Dysbiosis-Related Oral Biofilm Diseases: Antibiofilm, Antivirulence and Host Response Evidence.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Site-specific oral microbiome profiles in healthy young Korean women.Scientific reports · 2026Article
- Oral Microbiota, the Oral-Brain Axis, and Neurodegeneration: Mechanisms and Dietary Modulation.Antioxidants (Basel, Switzerland) · 2026Review
- Toothbrushing Ability in Older Adults Across Stages of Cognitive Impairment.Geriatrics (Basel, Switzerland) · 2026Article
- Article
- Silver nanoparticles in biomedicine: green synthesis, precision theranostics, and future clinical translation.Folia microbiologica · 2026Review
- [The Oral Microbiome: Maintenance of Homeostasis, Disease Associations, and Mechanisms of Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Silymarin inhibits osteoclastogenesis and alleviates inflammatory injury in RAW264.7 cells via activating the AMPK/Sirt1-autophagy axis.Scientific reports · 2026Article
150 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The human oral cavity harbors diverse communities of microbes that live as biofilms: highly ordered, surface-associated assemblages of microbes embedded in an extracellular matrix. Oral microbial communities contribute to human health by fine-tuning immune responses and reducing dietary nitrate. Dental caries and periodontal disease are together the most prevalent microbially mediated human diseases worldwide. Both of these oral diseases are known to be caused not by the introduction of exogenous pathogens to the oral environment, but rather by a homeostasis breakdown that leads to changes in the structure of the microbial communities present in states of health. Both dental caries and periodontal disease are mediated by synergistic interactions within communities, and both diseases are further driven by specific host inputs: diet and behavior in the case of dental caries and immune system interactions in the case of periodontal disease. Changes in community structure (taxonomic identity and abundance) are well documented during the transition from health to disease. In this review, changes in biofilm physical structure during the transition from oral health to disease and the concomitant relationship between structure and community function will be emphasized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.