Evidence map›Paper›PMID 31103439›Full record

ArticleThe American journal of pathology2019

CD55 Is Essential for CD103

Michael G Strainic, Jinbo Liu, Fengqi An, Erin Bailey, Andrew Esposito, Jörg Hamann, Peter S Heeger, M Edward Medof

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Critical Role of CD55 in Controlling Wound Healing.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Michael G StrainicInstitute of Pathology, Case Western Reserve University, Cleveland, Ohio.
Jinbo LiuInstitute of Pathology, Case Western Reserve University, Cleveland, Ohio.
Fengqi AnInstitute of Pathology, Case Western Reserve University, Cleveland, Ohio.
Erin BaileyInstitute of Pathology, Case Western Reserve University, Cleveland, Ohio.
Andrew EspositoDepartment of Ophthalmology, Case Western Reserve University, Cleveland, Ohio.
Jörg HamannDepartment of Experimental Immunology, University of Amsterdam, Academic Medical Center, Amsterdam, the Netherlands.
Peter S HeegerTransplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York.
M Edward MedofInstitute of Pathology, Case Western Reserve University, Cleveland, Ohio. Electronic address: mxm16@case.edu.
Case Western Reserve University · USAcademic Medical Center · NLIcahn School of Medicine at Mount Sinai · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Complement & T Cell Medicated Allograft RejectionR01AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2007 to 2016
$4.3M
Optimizing mesenchymal stem cell and Treg immunosuppression for controlling SLER01AR067182 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI MEDOF, MELVIN EDWARD · 2015 to 2019
$1.7M
Local Complement Synthesis and Signaling by Endothelial and Inflammatory CellsR01HL109561 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MEDOF, MELVIN EDWARD · 2012 to 2015
$1.5M
PROTECTION OF THE OCULAR SURFACER01EY011288 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI MEDOF, MELVIN EDWARD · 1996 to 2006
$1.5M
Complement & T Cell Medicated Allograft RejectionR56AI071185 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HEEGER, PETER SCOTT · 2012 to 2012
$339k
NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY011288NHLBI NIH HHS R01 HL109561NIAID NIH HHS R01 AI071185NIAID NIH HHS R56 AI071185NIAMS NIH HHS R01 AR067182
6 · The paper itself

Abstract

Recent studies traced inflammatory bowel disease in some patients to deficiency of CD55 [decay-accelerating factor (DAF)], but the mechanism underlying the linkage remained unclear. Herein, we studied the importance of DAF in enabling processes that program tolerance in the gut and the eye, two immune-privileged sites where immunosuppressive responses are continuously elicited. Unlike oral feeding or ocular injection of ovalbumin in wild-type (WT) mice, which induced dominant immune tolerance, identical treatment of DAF

Indexed as

Immune ToleranceAnimalsAntigens, CDAutoimmune DiseasesCD55 AntigensDendritic CellsIntegrin alpha ChainsIntegrin beta ChainsMiceMice, KnockoutT-Lymphocytes, Regulatoryalpha E integrinsAntigens, CDCD55 AntigensIntegrin alpha Chainsintegrin beta6integrin beta8Integrin beta Chains

Identifiers

PMID31103439
PMCPMC6617008
OpenAlexW2945695935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.