ArticleThe Annals of thoracic surgery2019
Impact of Microbiological Organism Type on Surgically Managed Endocarditis.
Article in The Annals of thoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Prosthetic Valve Endocarditis: A Retrospective Cohort Study Conducted at "Dr. Carol Davila" Central Military Emergency University Hospital in Bucharest.Microorganisms · 2024Article
- Sutureless aortic valve replacement in patients with active infective endocarditis: is it contraindicated or recommended?Journal of thoracic disease · 2022Article
- Surgical Procedure Time and Mortality in Patients with Infective Endocarditis Caused byJournal of clinical medicine · 2022Article
- Characteristics of infective endocarditis in a cancer population.Open heart · 2021Article
- The Evolving Burden of Drug Use Associated Infective Endocarditis in the United States.The Annals of thoracic surgery · 2020Article
- Should we include microorganisms in scores to predict outcome in candidates for cardiac surgery during the acute phase of endocarditis?Journal of thoracic disease · 2019Article
- Bugs at the operating theatre in infective endocarditis: one step forward, still a long way to go.Journal of thoracic disease · 2019Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study describes the impact of organism and valve type on surgically managed infective endocarditis (IE) from The Society of Thoracic Surgeons (STS) database. We developed a risk model for surgically managed endocarditis that includes the microbiological organism.
methodsThe STS database was queried for adult patients with surgically managed endocarditis from July 1, 2011, to June 30, 2016. Outcomes were compared based on (1) causative microbiological organism, (2) valve type (native vs prosthetic), and (3) endocarditis on the right (tricuspid) vs left (mitral, aortic) sides. Univariate and risk adjusted models were developed with odds ratios for mortality for each organism type referenced against Streptococcus.
resultsThe study population included 21,388 operations (93%) for left-sided IE and 1698 (7%) for right-sided IE. Streptococcus (28%) and Staphylococcus (27%) were the most common infecting organisms, followed by Enterococcus (11%). After multivariate adjustment, microbiological organism type was significantly associated with operative mortality for patients with left-sided endocarditis, with an adjusted odds ratio of 2.9 for fungal, 1.4 for Staphylococcus, and 1.3 for culture-negative vs Streptococcus. For right-sided endocarditis, there were no differences in outcomes by organism type. Left-sided prosthetic valve endocarditis had a higher operative mortality than left-sided native valve endocarditis (12% vs 8%, P < .001). In contrast, surgery for right-sided endocarditis carried lower operative mortality, with no mortality difference between prosthetic valve endocarditis and native valve endocarditis (5% vs 4%, P = .6).
conclusionsOrganism type influences the operative mortality for left-sided endocarditis. Surgery for left-sided and prosthetic valve endocarditis is associated with higher operative mortality. Risk adjustment for operative outcomes in endocarditis may need to account for microbiological organism type.
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