ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2019
Coronary Microvascular Dysfunction by Myocardial Contrast Echocardiography in Nonelderly Patients Referred for Computed Tomographic Coronary Angiography.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Evaluation of non-invasive imaging parameters in coronary microvascular disease: a systematic review.BMC medical imaging · 2021Pooled it
- Myocardial contrast echocardiography assessment of perfusion abnormalities in hypertrophic cardiomyopathy.Cardiovascular ultrasound · 2022Trial
- Atypical Presentations of Coronary Microvascular Dysfunction in Patients After COVID.JACC. Case reports · 2026Article
- 2026 Focused Update of the Saudi Heart Association Guidelines on Best Practices in the Management of Chronic Coronary Syndromes.Journal of the Saudi Heart Association · 2026Article
- Cardiac CT in Non-Obstructive Coronary Artery Disease (NOCAD): A Literature Review.Journal of clinical medicine · 2025Review
- Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Emerging Imaging Techniques for Atherosclerosis in Systemic Immune-Mediated Inflammatory Conditions.Arteriosclerosis, thrombosis, and vascular biology · 2025Review
- Generation and characterisation of scalable and stable human pluripotent stem cell-derived microvascular-like endothelial cells for cardiac applications.Angiogenesis · 2024Article
- Emerging Pathway to a Precision Medicine Approach for Angina With Nonobstructive Coronary Arteries in Women.JACC. Advances · 2024Review
- The usefulness of contrast echocardiography in the evaluation of cardiac masses: a multicenter study.BMC cardiovascular disorders · 2024Article
- Comparative study of myocardial perfusion and coronary flow velocity reserve derived from adenosine triphosphate stress myocardial contrast echocardiography in coronary lesions with no/mild stenosis.Frontiers in cardiovascular medicine · 2024Article
- Association between Troponin Elevation and Decreased Myocardial Blood Flow Reserve in Patients without Obstructive Coronary Artery Disease.Cardiology · 2024Article
- Chinese expert consensus on the diagnosis and treatment of coronary microvascular diseases (2023 Edition).MedComm · 2023Review
- Endogenous Circadian System Increases Capacity for Enhanced Coronary Microvascular Function in the Morning.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Strengths and weaknesses of alternative noninvasive imaging approaches for microvascular ischemia.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Dynamic evolution of left ventricular strain and microvascular perfusion assessed by speckle tracking echocardiography and myocardial contrast echocardiography in diabetic rats: Effect of dapagliflozin.Frontiers in cardiovascular medicine · 2023Article
- A novel risk stratification model for STEMI after primary PCI: global longitudinal strain and deep neural network assisted myocardial contrast echocardiography quantitative analysis.Frontiers in cardiovascular medicine · 2023Article
- Resting coronary flow drives the daily pattern in coronary flow reserve in patients with chest pain without obstructive epicardial stenosis.Frontiers in cardiovascular medicine · 2023Article
- Surveillance of adenosine stress myocardial contrast echocardiography following percutaneous coronary intervention.The international journal of cardiovascular imaging · 2022Article
- Advanced Echocardiography Techniques: The Future Stethoscope of Systemic Diseases.Current problems in cardiology · 2022Review
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMicrovascular dysfunction (MVD) is a potential cause of chest pain in younger individuals. The authors hypothesized that nonelderly patients referred for computed tomographic angiography (CTA) but without significant stenosis would have a high prevalence of MVD by myocardial contrast echocardiography (MCE). Secondary aims were to test whether the presence of nonobstructive coronary artery disease (CAD) or reduced brachial flow-mediated dilation (FMD) predicted MVD.
methodsSubjects ≤60 years of age undergoing CTA were recruited if they had either no evidence of coronary plaque or evidence of mild CAD (<50% stenosis) and at least one high-risk plaque feature. Subjects underwent quantitative perfusion imaging using MCE at rest and during regadenoson vasodilator stress. MVD was defined as global or segmental delay of microvascular refill (≥2 sec) during regadenoson. FMD of the brachial artery was also performed.
resultsOf the 29 patients in whom MCE could be performed, 12 (41%) had MVD. These subjects, compared with those with normal microvascular function, had lower hyperemic perfusion (mean, 236 ± 68 vs 354 ± 161 intensity units/sec; P = .02) and microvascular flux rate (mean, 1.6 ± 0.4 vs 2.5 ± 0.9 sec
conclusionsMVD is a common finding in the nonelderly population referred for CTA for evaluation of possible CAD but without obstructive stenosis. Neither the presence of noncritical atherosclerotic disease nor abnormal FMD increases the likelihood for detecting MVD in this population.
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