ReviewThe Veterinary clinics of North America. Food animal practice2019
Overgrowth Syndrome.
Review in The Veterinary clinics of North America. Food animal practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Offspring physiology following the use of IVM, IVF and ICSI: a systematic review and meta-analysis of animal studies.Human reproduction update · 2023Pooled it
- The Maternal Blood Transcriptome Reflects Changes in Fetal Growth and Is an Accurate Predictor of Birth Weight in Cattle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Beckwith-Wiedemann syndrome and large offspring syndrome involve alterations in methylome, transcriptome, and chromatin configuration.NAR molecular medicine · 2025Article
- Dynamic methylation pattern of H19DMR and KvDMR1 in bovine oocytes and preimplantation embryos.Journal of assisted reproduction and genetics · 2024Article
- Bovine embryo productionAnimal reproduction · 2024Review
- Role of the placenta in developmental programming: Observations from models using large animals.Animal reproduction science · 2023Review
- Hematological Normality, Serum Biochemistry, and Acute Phase Proteins in Healthy Beef Calves in the Brazilian Savannah.Animals : an open access journal from MDPI · 2023Article
- Defining Candidate Imprinted loci inGenes · 2023Article
- Review: Some challenges and unrealized opportunities toward widespread use of the in vitro-produced embryo in cattle production.Animal : an international journal of animal bioscience · 2023Review
- Epigenetic Reprogramming and Somatic Cell Nuclear Transfer.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Spontaneous and ART-induced large offspring syndrome: similarities and differences in DNA methylome.Epigenetics · 2022Article
- In vitro- and in vivo-produced male dairy calves show molecular differences in the hepatic and muscular energy regulation†.Biology of reproduction · 2022Article
- Along the Bos taurus genome, uncover candidate imprinting control regions.BMC genomics · 2022Article
- Identification of large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses.Scientific reports · 2022Article
- Allele-specific aberration of imprinted domain chromosome architecture associates with large offspring syndrome.iScience · 2022Article
- Differentially expressed tRNA-derived fragments in bovine fetuses with assisted reproduction induced congenital overgrowth syndrome.Frontiers in genetics · 2022Article
- Epigenomic and transcriptomic analyses reveal early activation of the HPG axis in in vitro-produced male dairy calves.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Developmental Plasticity in Response to Embryo Cryopreservation: The Importance of the Vitrification Device in Rabbits.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Large offspring syndrome (LOS) is a fetal overgrowth condition in bovines most often observed in offspring conceived with the use of assisted reproductive technologies (ART). Phenotypes observed in LOS include, overgrowth, enlarged tongues, umbilical hernias, muscle and skeleton malformations, abnormal organ growth and placental development. Although LOS cases have only been reported to be associated with ART, fetal overgrowth can occur spontaneously in cattle (S-LOS). S-LOS refers to oversized calves that are born at normal gestation lengths. ART-induced LOS has been characterized as an epigenetic syndrome, more specifically, a loss-of-imprinting condition. We propose that S-LOS is also a loss-of-imprinting condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.