Trial reportClinical pharmacology and therapeutics2019
Positron Emission Tomography Imaging of [
Abstract readClinical Trial
In one paragraph
Trial report in Clinical pharmacology and therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Biodistribution of Cerivastatin, Repaglinide, Glyburide, Rosuvastatin, and Valsartan in Cynomolgus Monkeys and PBPK Analysis.The AAPS journal · 2026Article
- Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model.CPT: pharmacometrics & systems pharmacology · 2026Article
- Rosuvastatin PBPK Modeling: Incorporating Liver Concentrations and Effects of Ethnicity, Genetic Polymorphisms, Lactone Formation, DDI and Pregnancy.CPT: pharmacometrics & systems pharmacology · 2025Article
- Effect of probenecid on the whole-body disposition of 6-bromo-7-[European journal of nuclear medicine and molecular imaging · 2025Article
- Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure.Acta pharmaceutica Sinica. B · 2025Article
- Cyclosporine A sterically inhibits statin transport by solute carrier OATP1B1.The Journal of biological chemistry · 2025Article
- Development of quantitative PET/MR imaging for measurements of hepatic portal vein input function: a phantom study.EJNMMI physics · 2024Article
- Physiologically based pharmacokinetics modeling and transporter proteomics to predict systemic and local liver and muscle disposition of statins.CPT: pharmacometrics & systems pharmacology · 2024Article
- Performance and Sensitivity of [Molecular pharmaceutics · 2024Article
- Toward improved predictions of pharmacokinetics of transported drugs in hepatic impairment: Insights from the extended clearance model.CPT: pharmacometrics & systems pharmacology · 2024Article
- Positron Emission Tomography-Based Pharmacokinetic Analysis To Assess Renal Transporter-Mediated Drug-Drug Interactions of Antimicrobial Drugs.Antimicrobial agents and chemotherapy · 2023Article
- Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug-Drug Interactions in Rats.Pharmaceutics · 2023Article
- Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective.Clinical pharmacology and therapeutics · 2022Review
- Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions.Clinical pharmacology and therapeutics · 2022Article
- Advancing Estimation of Hepatobiliary Clearances in Physiologically Based Pharmacokinetic Models of Rosuvastatin Using Human Hepatic Concentrations.Pharmaceutical research · 2021Article
- Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions.Pharmaceutical research · 2021Article
- Application of a PBPK model to elucidate the changes of systemic and liver exposures for rosuvastatin, carotegrast, and bromfenac followed by OATP inhibition in monkeys.Clinical and translational science · 2021Article
- Comparison of Hepatic Transporter Tissue Expression in Rodents and Interspecies Hepatic OCT1 Activity.The AAPS journal · 2021Article
- Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization.Journal of medicinal chemistry · 2021Review
- Evaluation of Pharmacokinetic Drug-Drug Interactions: A Review of the Mechanisms, In Vitro and In Silico Approaches.Metabolites · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 8 institutions in 3 countries.
Sarah BillingtonDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Steven ShonerDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Scott LeeInflammatory Bowel Disease Program, University of Washington, Seattle, Washington, USA.
Kindra Clark-SnustadInflammatory Bowel Disease Program, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-1948-0780
Matthew PenningtonDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, Washington, USA.
David LewisDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Mark MuziDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Shirley ReneDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Jean LeeDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Tot Bui NguyenDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Vineet KumarDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Kazuya IshidaDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
Laigao ChenEarly Clinical Development, Worldwide Research and Development, Pfizer Inc., Cambridge, Massachusetts, USA.
Xiaoyan ChuPharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Kenilworth, New Jersey, USA.
Yurong LaiDepartment of Drug Metabolism, Gilead Sciences, Inc., Foster City, California, USA.ORCID 0000-0001-9505-333X
Laurent SalphatiDrug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Cornelis E C A HopDrug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California, USA.
Guangqing XiaoDrug Metabolism and Pharmacokinetics, Biogen, Cambridge, Massachusetts, USA.
Mingxiang LiaoDepartment of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
Jashvant D UnadkatDepartment of Pharmaceutics, University of Washington, Seattle, Washington, USA.
University of Washington · USGenentechAmgen (United States) · USBiogen (United States) · USGilead Sciences (United Kingdom) · GBMerck & Co., Inc., Rahway, NJ, USA (United States) · USPfizer (United States) · USTakeda (United States) · US
Funding
Core Laboratory for Advanced PET and MRI image analysisR50CA211270 · NCI · UNIVERSITY OF WASHINGTON · PI Mark Muzi · 2017 to 2026
$2.6MNCI NIH HHS R50 CA211270
Abstract
Using positron emission tomography imaging, we determined the hepatic concentrations and hepatobiliary transport of [
Indexed as
ATP Binding Cassette Transporter, Subfamily G, Member 2BilirubinBiological TransportCarbon RadioisotopesCoproporphyrinsCyclosporineDrug InteractionsHumansLiverMetabolic Clearance RateOrganic Anion Transporters, Sodium-DependentPositron-Emission TomographyRosuvastatin CalciumSymportersTissue DistributionATP Binding Cassette Transporter, Subfamily G, Member 2BilirubinCarbon RadioisotopesCoproporphyrinsCyclosporineOrganic Anion Transporters, Sodium-DependentRosuvastatin Calciumsodium-bile acid cotransporterSymporters
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.