Evidence map›Paper›PMID 31102440›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019

Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome-like Clinical Presentation in Human Immunodeficiency Virus-infected Children in Malawi.

Nader Kim El-Mallawany, William Kamiyango, Jimmy Villiera, Erin C Peckham-Gregory, Michael E Scheurer, Casey L McAtee, Carl E Allen, Carrie L Kovarik, Dale Frank, Anthony B Eason and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  8. Review
  9. Malignancy and viral infections in Sub-Saharan Africa: A review.Frontiers in virology (Lausanne, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Nader Kim El-MallawanyBaylor College of Medicine.
William KamiyangoBaylor College of Medicine Children's Foundation Malawi, Lilongwe.
Jimmy VillieraBaylor College of Medicine Children's Foundation Malawi, Lilongwe.
Erin C Peckham-GregoryBaylor College of Medicine.
Michael E ScheurerBaylor College of Medicine.
Casey L McAteeBaylor College of Medicine.
Carl E AllenBaylor College of Medicine.
Carrie L KovarikUniversity of Pennsylvania, Philadelphia.
Dale FrankUniversity of Pennsylvania, Philadelphia.
Anthony B EasonLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill.
Carolina Caro-VegasLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill.
Elizabeth Y ChiaoCenter for Innovation, Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center.
Gordon E SchutzeBaylor College of Medicine.
Nmazuo W OzuahBaylor College of Medicine.
Parth S MehtaBaylor College of Medicine.
Peter N KazembeBaylor College of Medicine Children's Foundation Malawi, Lilongwe.
Dirk P DittmerLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill.
Baylor College of Medicine · USChildren's Cancer Center · USLilongwe University of Agriculture and Natural Resources · MWUniversity of North Carolina at Chapel Hill · USPhiladelphia University · USTexas Children's Hospital · USUniversity of Pennsylvania · US

Funding

Vironomics and Biostatistics CoreP01CA019014 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BLOSSOM A DAMANIA, NANCY JOAN RAAB-TRAUB · 1985 to 2026
$43.8M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
Project 3U54CA190152 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, GOPAL, SATISH · 2014 to 2019
$4.2M
Mechanisms of KSHV TransmissionR01CA239583 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, DITTMER, DIRK P · 2019 to 2023
$2.8M
Impact of HIV on the Tumor MicroenvironmentR01CA228172 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAMANIA, BLOSSOM A, DITTMER, DIRK P · 2018 to 2022
$2.0M
(PQ5) Exploring the Biological Distinctions between HIV-related and Endemic Pediatric Kaposi Sarcoma in a Kaposi Sarcoma-Associated Herpesvirus-Endemic Region of AfricaR21CA217137 · NCI · BAYLOR COLLEGE OF MEDICINE · PI EL-MALLAWANY, NADER KIM · 2017 to 2018
$412k
Origin and Lineage of Differentiation of Kaposi's SarcomaR21CA192744 · NCI · STELLENBOSCH UNIVERSITY · PI DITTMER, DIRK P, SCHNEIDER, JOHANN WILHELM · 2015 to 2016
$346k
NCI NIH HHS P01 CA019014NCI NIH HHS R21 CA192744NCI NIH HHS R21 CA217137NCI NIH HHS U54 CA190152NIAID NIH HHS P30 AI036211
6 · The paper itself

Abstract

We describe 7 human immunodeficiency virus-infected Malawian children with Kaposi sarcoma who met criteria for Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome. Each presented with persistent fevers, bulky lymphadenopathy, massive hepatosplenomegaly, and severe cytopenias. Plasma analyses were performed in 2 patients, both demonstrating extreme elevations of KSHV viral load and interleukin 6.

Indexed as

ChildChild, PreschoolCytokinesFemaleHerpesvirus 8, HumanHIV InfectionsHumansInterleukin-6LymphadenopathyMalawiMaleProspective StudiesRetrospective StudiesSarcoma, KaposiCytokinesInterleukin-6human herpesvirus 8Kaposi sarcomaKaposi sarcoma herpesvirusKaposi sarcoma herpesvirus inflammatory cytokine syndromepediatric oncology

Identifiers

PMID31102440
PMCPMC6853646
OpenAlexW2924875274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.