Evidence map›Paper›PMID 31102409›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Contribution of Congenital Cytomegalovirus Infection to Permanent Hearing Loss in a Highly Seropositive Population: The Brazilian Cytomegalovirus Hearing and Maternal Secondary Infection Study.

Aparecida Y Yamamoto, Adriana R T Anastasio, Eduardo T Massuda, Myriam L Isaac, Alessandra K S Manfredi, Juliana M S Cavalcante, Adriana Carnevale-Silva, Karen B Fowler, Suresh B Boppana, William J Britt and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04822142 (Congenital Cytomegalovirus Infection in Vietnam), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04822142 unknown statusnot on this mapstarted 2022, after this paper: background citation

Congenital Cytomegalovirus Infection in Vietnam: Prevalence, Morbidity and Risk Factors

Typeobservational_patient_registrySponsorHanoi Obstetrics and Gynecology HospitalRan2022 to 2026Enrolled5,000ConditionsPrenatal Infection, Congenital Infection, Neonatal Disease
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  10. Congenital Cytomegalovirus Testing Outcomes From the ValEAR Trial.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024
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  19. Comprehensive evaluation of risk factors for neonatal hearing loss in a large Brazilian cohort.Journal of perinatology : official journal of the California Perinatal Association · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Aparecida Y YamamotoDepartment of Pediatrics, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Adriana R T AnastasioDepartment of Health Sciences, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Eduardo T MassudaDepartment of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Myriam L IsaacDepartment of Ophthalmology, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Alessandra K S ManfrediDepartment of Health Sciences, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Juliana M S CavalcanteDepartment of Health Sciences, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Adriana Carnevale-SilvaDepartment of Pediatrics, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.
Karen B FowlerDepartment of Pediatrics, University of Alabama School of Medicine, Birmingham.
Suresh B BoppanaDepartment of Pediatrics, University of Alabama School of Medicine, Birmingham.
William J BrittDepartment of Pediatrics, University of Alabama School of Medicine, Birmingham.
Marisa M Mussi-PinhataDepartment of Pediatrics, Otorhinolaryngology, and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Brazil.

Funding

CMV Vaccines: Reinfection and Antigenic Variation (Vision and auditory screening in infants born to women enrolled in ZIP)R01HD061959 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, MUSSI-PINHATA, MARISA MARCIA · 2011 to 2023
$5.9M
NICHD NIH HHS R01 HD061959
6 · The paper itself

Abstract

backgroundThe exact contribution of congenital cytomegalovirus infection (cCMVI) to permanent hearing loss (HL) in highly seropositive populations is unknown. We determined the contribution of cCMVI to HL and estimated the effectiveness of newborn hearing screening (HS) in identifying neonates with CMV-related HL.

methodsA total of 11 900 neonates born from a population with ≥97% maternal seroprevalence were screened for cCMVI and HL. cCMVI was confirmed by detection of CMV-DNA in saliva and urine at age <3 weeks.

resultsOverall, 68 (0.6%; 95% confidence interval [CI], 0.4-0.7) neonates were identified with cCMVI. Of the 91 (0.8%) newborns who failed the HS, 24 (26.4%) were confirmed with HL, including 7 (29.2%; 95% CI, 17.2-59.3) with cCMVI. Another newborn with cCMVI passed the HS but was confirmed with HL at age 21 days. Of the 62 neonates with cCMVI who underwent a complete hearing evaluation, 8 (12.9%; 95% CI, 6.7-23.4) had HL and most (7/8; 87.5%; 95% CI, 46.6-99.7) were identified by HS. The rate of CMV-related HL was 8 per 11 887 neonates (0.7 per 1000 live births). The prevalence ratio of HL among neonates with cCMVI compared to CMV-uninfected neonates was 89.5 (95% CI, 39.7-202.0). No late-onset cCMVI-related HL was detected during a median follow-up of 36 months.

conclusionscCMVI is an important cause of HL in childhood in all settings. Integrating targeted cCMVI screening among neonates who fail a HS could be a reasonable, cost-effective strategy to identify newborns with early-onset cCMVI-related HL.

Indexed as

CoinfectionCytomegalovirus InfectionsAdultBrazilChildCytomegalovirusHearingHumansInfant, NewbornSeroepidemiologic StudiesYoung AdultCMV screeningcongenital infectioncytomegalovirushearing screeningHL

Identifiers

PMID31102409
PMCPMC7931844

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.