Evidence map›Paper›PMID 31102328›Full record

Trial reportESC heart failure2019

High vs. low oxygen therapy in patients with acute heart failure: HiLo-HF pilot trial.

Nariman Sepehrvand, Wendimagegn Alemayehu, Brian H Rowe, Finlay A McAlister, Sean van Diepen, Michael Stickland, Justin A Ezekowitz

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in ESC heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Conservative versus liberal oxygen therapy in mechanically ventilated patients: A systematic review with meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2025
    Pooled it
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  7. Review
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  9. A study on the rapid diagnosis of chronic heart failure by measuring the difference in pulse oxygen saturation before and after arm compression.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nariman SepehrvandCanadian VIGOUR Centre, University of Alberta, 2-132 Li Ka Shing Centre for Health Research Innovation, Edmonton, Alberta, Canada, T6G 2E1.
Wendimagegn AlemayehuCanadian VIGOUR Centre, University of Alberta, 2-132 Li Ka Shing Centre for Health Research Innovation, Edmonton, Alberta, Canada, T6G 2E1.
Brian H RoweDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Finlay A McAlisterCanadian VIGOUR Centre, University of Alberta, 2-132 Li Ka Shing Centre for Health Research Innovation, Edmonton, Alberta, Canada, T6G 2E1.
Sean van DiepenCanadian VIGOUR Centre, University of Alberta, 2-132 Li Ka Shing Centre for Health Research Innovation, Edmonton, Alberta, Canada, T6G 2E1.
Michael SticklandDivision of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Justin A EzekowitzCanadian VIGOUR Centre, University of Alberta, 2-132 Li Ka Shing Centre for Health Research Innovation, Edmonton, Alberta, Canada, T6G 2E1.
Canadian VIGOUR Centre · CAUniversity of Alberta · CAProvincial Laboratory of Public Health · CA

Funding

Alberta Innovates - Health SolutionsCIHRGovernment of CanadaHeart and Stroke Foundation of CanadaUniversity of Alberta
6 · The paper itself

Abstract

aimsMost patients with acute heart failure (AHF) are treated with supplemental oxygen during hospitalization. In this study, we investigated the effect of oxygen titrated to high vs. low pulse oximetry targets in patients hospitalized with AHF. METHODS AND

resultsIn a pilot, open-label randomized controlled trial (RCT), 50 patients who were admitted with AHF were randomized to either high (≥96%) or low (90-92%) SpO

conclusionsIn this study, no differences were observed in the primary or secondary outcomes for patients randomized to high vs. low SpO

Indexed as

Acute DiseaseAgedAged, 80 and overFemaleHeart FailureHumansMaleMiddle AgedOxygenOxygen Inhalation TherapyPilot ProjectsOxygenHeart failureRandomized controlled trialSupplemental oxygen

Identifiers

PMID31102328
PMCPMC6676301
OpenAlexW2945185398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.