ArticleAnnals of neurology2019
Residual descending motor pathways influence spasticity after spinal cord injury.
Article in Annals of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- A Novel Wearable Device for Motor Recovery of Hand Function in Chronic Stroke Survivors.Neurorehabilitation and neural repair · 2020Trial
- Descending Brainstem Systems Contribute to Ankle Clonus in Humans with Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spasticity and Abnormal Tone Regulation After Spinal Cord Injury: Mechanisms and the Effects of Neuromodulation.Biomedicines · 2026Review
- Enhanced Reticulospinal Output in Subacute Spinal Cord Injury Patients with Spasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Reduced Post-Activation Depression in Humans with Spinal Cord Injury Is Not Related to Stretch Reflex Hyperexcitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Repetitive Transcranial Magnetic Stimulation for the Treatment of Spinal Cord Injury: Current Status and Perspective.International journal of molecular sciences · 2025Review
- Exploring the Landscape of Biomarkers in Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2025Review
- Corticospinal Tract Sparing in Cervical Spinal Cord Injury.Journal of clinical medicine · 2024Article
- A portable system to measure knee extensor spasticity after spinal cord injury.Journal of neuroengineering and rehabilitation · 2024Article
- Magnetic Stimulation of Gigantocellular Reticular Nucleus with Iron Oxide Nanoparticles Combined Treadmill Training Enhanced Locomotor Recovery by Reorganizing Cortico-Reticulo-Spinal Circuit.International journal of nanomedicine · 2024Article
- Article
- Spasticity Predicts Motor Recovery for Patients with Subacute Motor Complete Spinal Cord Injury.Annals of neurology · 2023Article
- Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections.Nature communications · 2023Article
- [Water tank scale: a reliable method for assessing motor function after spinal cord injury in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Noxious radiant heat evokes bi-component nociceptive withdrawal reflexes in spinal cord injured humans-A clinical tool to study neuroplastic changes of spinal neural circuits.Frontiers in human neuroscience · 2023Article
- Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review.Frontiers in nutrition · 2023Review
- Spinal cord associative plasticity improves forelimb sensorimotor function after cervical injury.Brain : a journal of neurology · 2022Article
- Prevalence of spasticity in humans with spinal cord injury with different injury severity.Journal of neurophysiology · 2022Article
- Influence of Spinal Shock on the Neurorehabilitation of ANNPE Dogs.Animals : an open access journal from MDPI · 2022Article
- MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys.Experimental animals · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveSpasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). The neural mechanisms contributing to its development are not yet understood. Using neurophysiological and imaging techniques, we examined the influence of residual descending motor pathways on spasticity in humans with SCI.
methodsWe measured spasticity in 33 individuals with motor complete SCI (determined by clinical examination) without preservation of voluntary motor output in the quadriceps femoris muscle. To examine residual descending motor pathways, we used magnetic and electrical stimulation over the leg motor cortex to elicit motor evoked potentials (MEPs) in the quadriceps femoris muscle and structural magnetic resonance imaging to measure spinal cord atrophy.
resultsWe found that 60% of participants showed symptoms of spasticity, whereas the other 40% showed no spasticity, demonstrating the presence of 2 clear subgroups of humans with motor complete SCI. MEPs were only present in individuals who had spasticity, and MEP size correlated with the severity of spasticity. Spinal cord atrophy was greater in nonspastic compared with spastic subjects. Notably, the degree of spared tissue in the lateral regions of the spinal cord was positively correlated with the severity of spasticity, indicating preservation of white matter related to motor tracts when spasticity was present.
interpretationThese results support the hypothesis that preservation of descending motor pathways influences spasticity in humans with motor complete SCI; this knowledge might help the rehabilitation and assessment of people with SCI. ANN NEUROL 2019.
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