ReviewDevelopmental psychobiology2019
Co-activation of SAM and HPA responses to acute stress: A review of the literature and test of differential associations with preadolescents' internalizing and externalizing.
Review in Developmental psychobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Adrenocortical and autonomic cross-system regulation in youth: A meta-analysis.Psychoneuroendocrinology · 2024Pooled it
- Correlations between negative life events and suicidal ideation among Chinese adolescents: a meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Effect of Virtual Reality Distraction Method on the Level of Salivary Cortisol in Children With Autism Spectrum Disorder During Dental Treatment.Journal of autism and developmental disorders · 2026Trial
- Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events.Development and psychopathology · 2020Trial
- Stress sensitization among severely neglected children and protection by social enrichment.Nature communications · 2019Trial
- Dysregulated neuroendocrine stress response and blood pressure management burden are linked to remote diffusion-weighted imaging lesions after intracerebral hemorrhage: a prospective pilot study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Differential associations of oxidative stress parameters with neuroendocrine markers and hemodynamic reactivity in acute mental stress-induced adrenergic reactivity profiles: The SABPA study.Physiological reports · 2026Article
- Altered peripheral blood mRNA and salivary biomarkers in dental anxiety: a cross-sectional study.BMC oral health · 2026Article
- From Stress to Neurodegeneration: A New Look at the Pathogenesis of Parkinson's Disease.Biomedicines · 2026Review
- Resting neuroendocrine markers in relation to acute mental stress-induced adrenergic reactivity profiles in adults: The SABPA study.Physiological reports · 2026Article
- C-Ring Structure-Dependent Redox Properties of Flavonoids Regulate the Expression of Bioactivity.Antioxidants (Basel, Switzerland) · 2026Article
- A quantitative, multimodal wearable bioelectronic device for comprehensive stress assessment and sub-classification.Nature communications · 2026Article
- Virtual stress testing: Analyzing endocrine, metabolic, cardiovascular, and psychological responses to the TSST-VR.Neurobiology of stress · 2025Article
- Neighborhood air quality, psychobiological reactivity, and mental health across adolescence.Environmental science and pollution research international · 2025Article
- Restoration of typical HPA-SAM co-activation following psychosocial intervention among preadolescent youth living in poverty.Development and psychopathology · 2025Article
- Prediabetes May Alter HPA Axis Activity and Regulation: A Study on Patients with Prediabetes.International journal of molecular sciences · 2025Article
- Role of C-Jun N-Terminal Kinases on a Stressed Epithelium: Time for Testing Isoform Specificity.Biology · 2025Review
- Simultaneous Determination of Tobacco Smoke Exposure and Stress Biomarkers in Saliva Using In-Tube SPME and LC-MS/MS for the Analysis of the Association between Passive Smoking and Stress.Molecules (Basel, Switzerland) · 2024Article
- Sensory Nutrition and Bitterness and Astringency of Polyphenols.Biomolecules · 2024Review
- Exploring metabolomic dynamics in acute stress disorder: amino acids, lipids, and carbohydrates.Frontiers in genetics · 2024Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Understanding co-activation patterns of the hypothalamic-pituitary-adrenal axis (HPA) and sympathetic adrenal medullary (SAM) during early adolescence may illuminate risk for development of internalizing and externalizing problems. The present study advances empirical work on the topic by examining SAM-HPA co-activation during both the reactivity and recovery phases of the stress response following acute stress exposure. Fourth and fifth grade boys and girls (N = 149) provided cortisol and alpha-amylase via saliva at seven times throughout a 95-min assessment in which they were administered the modified Trier Social Stress Test. Parents reported on adolescents' life stress, pubertal development, medication use, and externalizing problems. Adolescents reported their own internalizing symptoms. Multiple linear regressions tested both direct and interactive effects of SAM and HPA reactivity and recovery on internalizing and externalizing problems. Results from these analyses showed that whereas SAM and HPA reactivity interacted to predict internalizing symptoms, it was their interaction during the recovery phase that predicted externalizing. Concurrent high SAM and HPA reactivity scores predicted high levels of internalizing and concurrently low SAM and HPA recovery scores predicted high levels of externalizing. Implications of the findings for further study and clinical application are discussed.
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