Evidence map›Paper›PMID 31102158›Full record

ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2019

Patient and general population values for luminal and perianal fistulising Crohn's disease health states.

Fanni Rencz, Peep F M Stalmeier, Márta Péntek, Valentin Brodszky, Gábor Ruzsa, Lóránt Gönczi, Károly Palatka, László Herszényi, Eszter Schäfer, János Banai and 3 more

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In one paragraph

Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Time trade-off health state utility values for depression: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Pooled it
  2. Health State Utility Values: The Implications of Patient versus Community Ratings in Assessing the Value of Care.Medical decision making : an international journal of the Society for Medical Decision Making · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 3 countries.

Fanni RenczDepartment of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary. fanni.rencz@uni-corvinus.hu.ORCID http://orcid.org/0000-0001-9674-620X
Peep F M StalmeierRadboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.
Márta PéntekDepartment of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary.ORCID http://orcid.org/0000-0001-9636-6012
Valentin BrodszkyDepartment of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary.ORCID http://orcid.org/0000-0002-6095-2295
Gábor RuzsaDoctoral School of Psychology, Institute of Psychology, Eötvös Loránd University of Sciences, Izabella u. 46, 1064, Budapest, Hungary.ORCID http://orcid.org/0000-0002-6817-6454
Lóránt Gönczi1st Department of Medicine, Semmelweis University, Korányi Sándor u. 2/a, 1083, Budapest, Hungary.ORCID http://orcid.org/0000-0002-8819-6460
Károly PalatkaDivision of Gastroenterology, Department of Internal Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.ORCID http://orcid.org/0000-0001-7924-7951
László HerszényiMedical Centre, Hungarian Defence Forces, Podmaniczky u. 109-111, 1062, Budapest, Hungary.ORCID http://orcid.org/0000-0002-7454-4401
Eszter SchäferMedical Centre, Hungarian Defence Forces, Podmaniczky u. 109-111, 1062, Budapest, Hungary.
János BanaiMedical Centre, Hungarian Defence Forces, Podmaniczky u. 109-111, 1062, Budapest, Hungary.
Mariann Rutka1st Department of Internal Medicine, University of Szeged, Korányi fasor 8-10, 6720, Szeged, Hungary.ORCID http://orcid.org/0000-0003-2360-7836
László GulácsiDepartment of Health Economics, Corvinus University of Budapest, Fővám tér 8, 1093, Budapest, Hungary.ORCID http://orcid.org/0000-0002-9285-8746
Peter L Lakatos1st Department of Medicine, Semmelweis University, Korányi Sándor u. 2/a, 1083, Budapest, Hungary.ORCID http://orcid.org/0000-0002-3948-6488
Corvinus University of Budapest · HUZrínyi Miklós National Defence University · HUSemmelweis University · HUEötvös Loránd University · HURadboud University Nijmegen · NLUniversity of Debrecen · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn patients with Crohn's disease (CD), luminal disease activity paralleled by perianal fistulas may seriously impair health-related quality of life (HRQoL). Health utility values are not available from patients with CD that reflect the health loss associated with both luminal and perianal CD.

objectiveTo generate utilities for luminal and concomitant perianal fistulising CD health states directly from patients and from members of the general public.

methodsA cross-sectional survey was undertaken enrolling CD patients and a convenience sample of members of the general population. Respondents were asked to evaluate four common CD heath states [severe luminal disease (sCD), mild luminal disease (mCD), severe luminal disease with active perianal fistulas (sPFCD), and mild luminal disease with active perianal fistulas (mPFCD)] by 10-year time trade-off (TTO). In addition, patients assessed their current HRQoL by the TTO method.

resultsResponses of 206 patients (40.8% with perianal fistulas) and 221 members of the general population were analysed. Mean ± SD utilities among patients for sPFCD, sCD, mPFCD and mCD states were 0.69 ± 0.33, 0.73 ± 0.31, 0.80 ± 0.29 and 0.87 ± 0.26. Corresponding values in the general public were: 0.59 ± 0.31, 0.65 ± 0.29, 0.80 ± 0.26 and 0.88 ± 0.25. Patients with active perianal fistulas, previous non-resection surgeries, and higher pain intensity scores valued their current health as worse (p < 0.05).

conclusionsTTO is a feasible method to assess HRQoL in patients with perianal fistulising disease, often not captured by health status questionnaires. Utilities from this study are intended to support the optimization of treatment-related decision making in patients with luminal disease paralleled by active perianal fistulas.

Indexed as

AdolescentAdultAge FactorsAnus DiseasesCrohn DiseaseCross-Sectional StudiesDigestive System FistulaFemaleHumansMaleMiddle AgedQuality of LifeSeverity of Illness IndexSex FactorsSocioeconomic FactorsYoung AdultCrohn’s diseaseHungaryPerianal fistulaQALYQuality of lifeTime trade-offUtility

Identifiers

PMID31102158
PMCPMC6544586
OpenAlexW2946025675

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.