Evidence map›Paper›PMID 31102155›Full record

Observational studyQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2019

Use of an expert panel to identify domains and indicators of delirium severity.

Dena Schulman-Green, Eva M Schmitt, Tamara G Fong, Sarinnapha M Vasunilashorn, Jacqueline Gallagher, Edward R Marcantonio, Charles H Brown, Diane Clark, Joseph H Flaherty, Anne Gleason and 11 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Advancing specificity in delirium: The delirium subtyping initiative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  4. Article
  5. Domains of delirium severity in Alzheimer's disease and related dementias.Journal of the American Geriatrics Society · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Dena Schulman-GreenYale School of Nursing, P.O. Box 27399, West Haven, CT, 06516, USA. dena.schulman-green@yale.edu.ORCID http://orcid.org/0000-0003-2259-3284
Eva M SchmittInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Tamara G FongInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Sarinnapha M VasunilashornHarvard Medical School, Boston, MA, USA.
Jacqueline GallagherBeth Israel Deaconess Medical Center, Boston, MA, USA.
Edward R MarcantonioHarvard Medical School, Boston, MA, USA.
Charles H BrownSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Diane ClarkDept. of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, USA.
Joseph H FlahertyEnvision-Questcare Physician Services, Dallas, TX, USA.
Anne GleasonInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Sharon GordonVA Tennessee Valley Healthcare System, Nashville, TN, USA.
Ann M KolanowskiCollege of Nursing, Pennsylvania State University, University Park, PA, USA.
Karin J NeufeldSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Margaret O'ConnorBrigham and Women's Hospital, Boston, MA, USA.
Margaret A PisaniSchool of Medicine, Yale University, New Haven, CT, USA.
Thomas N RobinsonSchool of Medicine, University of Colorado, Denver, CO, USA.
Joe VergheseAlbert Einstein College of Medicine, Bronx, NY, USA.
Heidi L WaldSchool of Medicine, University of Colorado, Denver, CO, USA.
Richard N JonesWarren Alpert Medical School, Brown University, Providence, RI, USA.
Sharon K InouyeInstitute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
BASIL Study Group

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI TRAVISON, THOMAS GLENN · 2010 to 2022
$26.7M
READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly OrganizationsR01AG030618 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI DONNA Marie FICK, EDWARD R MARCANTONIO · 2008 to 2026
$7.9M
Development and Validation of a Delirium Severity ToolkitR01AG044518 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K., JONES, RICHARD N · 2014 to 2024
$7.3M
Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
Mid-Career Mentoring Award for Patient-Oriented Research in AgingK24AG035075 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R · 2010 to 2021
$1.9M
K07 Leadership GrantK07AG041835 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2013 to 2017
$656k
Shared Pathophysiology of Postoperative Delirium and Alzheimer’s Disease and Related DementiasK01AG057836 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VASUNILASHORN, SARINNAPHA · 2018 to 2022
$565k
Genetic and Neuroinflammatory Mechanisms of Delirium and Alzheimer’s Disease and Related DementiasR03AG061582 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI VASUNILASHORN, SARINNAPHA · 2019 to 2020
$175k
NIA NIH HHS K01 AG057836NIA NIH HHS K01AG057836NIA NIH HHS K07 AG041835NIA NIH HHS K07AG041835NIA NIH HHS K24 AG035075NIA NIH HHS K24AG035075NIA NIH HHS P01 AG031720NIA NIH HHS P01AG031720NIA NIH HHS R01 AG030618NIA NIH HHS R01AG030618NIA NIH HHS R01 AG044518NIA NIH HHS R01AG044518NIA NIH HHS R03 AG061582NIA NIH HHS R24 AG054259NIA NIH HHS R24AG054259
6 · The paper itself

Abstract

purposeOur purpose was to create a content domain framework for delirium severity to inform item development for a new instrument to measure delirium severity.

methodsWe used an established, multi-stage instrument development process during which expert panelists discussed best approaches to measure delirium severity and identified related content domains. We conducted this work as part of the Better ASsessment of ILlness (BASIL) study, a prospective, observational study aimed at developing and testing measures of delirium severity. Our interdisciplinary expert panel consisted of twelve national delirium experts and four expert members of the core research group. Over a one-month period, experts participated in two rounds of review.

resultsExperts recommended that the construct of delirium severity should reflect both the phenomena and the impact of delirium to create an accurate, patient-centered instrument useful to interdisciplinary clinicians and family caregivers. Final content domains were Cognitive, Level of consciousness, Inattention, Psychiatric-Behavioral, Emotional dysregulation, Psychomotor features, and Functional. Themes debated by experts included reconciling clinical geriatrics and psychiatric content, mapping symptoms to one specific domain, and accurate capture of unclear clinical presentations.

conclusionsWe believe this work represents the first application of instrument development science to delirium. The identified content domains are inclusive of various, wide-ranging domains of delirium severity and are reflective of a consistent framework that relates delirium severity to potential clinical outcomes. Our content domain framework provides a foundation for development of delirium severity instruments that can help improve care and quality of life for patients with delirium.

Indexed as

Severity of Illness IndexCaregiversDeliriumFemaleHumansMaleProspective StudiesQuality of LifeDeliriumExpert panelInstrument developmentSeverity

Identifiers

PMID31102155
PMCPMC6858057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.