Evidence map›Paper›PMID 31102149›Full record

ArticleMolecular biology reports2019

Anti-angiogenic activity of Gracilaria coronopifolia J.G. Agardh extract by lowering the levels of trace metals (iron, zinc and copper) in duck chorioallantoic membrane and in vitro activation of AMP-kinase.

Oliver B Villaflores, Katrin Mae M Ortega, Analin Empaynado-Porto, Stephen Lirio, Hwa-Kwang Yak, Dharmatov Rahula Albano, Mary Jho-Anne T Corpuz

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Oliver B VillafloresThe Graduate School, University of Santo Tomas, Manila, Philippines. obvillaflores@ust.edu.ph.
Katrin Mae M OrtegaThe Graduate School, University of Santo Tomas, Manila, Philippines.
Analin Empaynado-PortoThe Graduate School, University of Santo Tomas, Manila, Philippines.
Stephen LirioDepartment of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li, 320, Taiwan.
Hwa-Kwang YakDepartment of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li, 320, Taiwan.
Dharmatov Rahula AlbanoThe Graduate School, University of Santo Tomas, Manila, Philippines.
Mary Jho-Anne T CorpuzThe Graduate School, University of Santo Tomas, Manila, Philippines.
University of Santo Tomas · PHChung Yuan Christian University · TWOur Lady of Fatima University · PH

Funding

Department of Science and Technology, Republic of the Philippines (PH) DOST SEI SCHOLAR
6 · The paper itself

Abstract

AMP-activated protein kinase (AMPK) is an intracellular energy sensor important in metabolic regulation, cell growth, and survival. However, the specific role of AMPK signaling pathway in the inhibition of angiogenesis remains unclear. The study highlights the activity on AMP activated protein kinase signaling pathways of a marine algae, Gracilaria coronopifolia, and its effects on angiogenesis. It was found that the most potent extract, GCD, inhibited angiogenesis significantly in the duck chorioallantoic membrane assay and also activated the enzyme AMP-kinase, in vitro. The dichloromethane extract was found most active in inhibiting angiogenesis in the duck chorioallantoic membrane (IC

Indexed as

AMP-Activated Protein KinasesAngiogenesis InhibitorsAnimalsChorioallantoic MembraneCopperDucksGracilariaIronNeovascularization, PhysiologicOvumPlant ExtractsRhodophytaSignal TransductionZincAMP-Activated Protein KinasesAngiogenesis InhibitorsCopperIronPlant ExtractsZincAMP-activated protein kinaseAngiogenesisCAM assayGracilaria coronopifolia

Identifiers

PMID31102149
OpenAlexW2946698827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.