ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2019
Efficacy of the optimal ablation index-targeted strategy for pulmonary vein isolation in patients with atrial fibrillation: the OPTIMUM study results.
Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03389074 (Evaluation of OPTIMal Ablation Index for pUlMonary Vein Isolation in Patients With Atrial Fibrillation), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of OPTIMal Ablation Index for pUlMonary Vein Isolation in Patients With Atrial Fibrillation (OPTIMUM) Prospective Registry
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Safety and efficacy of the ThermoCool SmartTouch SurroundFlow catheter for atrial fibrillation ablation: A meta-analysis.Clinical cardiology · 2020Pooled it
- Atrial volumetrics and recurrence after catheter ablation for atrial fibrillation.Frontiers in cardiovascular medicine · 2026Article
- Ostial vs. wide area circumferential ablation guided by the Ablation Index in paroxysmal atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Performance of the ablation index during pulmonary vein isolation: periprocedural data from a multicenter registry.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- The effect of left atrial wall thickness and pulmonary vein sizes on the acute procedural success of atrial fibrillation ablation.The international journal of cardiovascular imaging · 2022Article
- Two years after pulmonary vein isolation guided by ablation index-a multicenter study.Journal of arrhythmia · 2022Article
- Impact of ablation index settings on pulmonary vein reconnection.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2022Article
- Tailored Target Ablation Index Guided Pulmonary Vein Isolation in Treating Paroxysmal Atrial Fibrillation: A Single Center Randomized Study in Asian Population (AI-Asian-I).Frontiers in cardiovascular medicine · 2022Article
- Catheter ablation and thoracoscopic ablation in long persistent atrial fibrillation with large left atrium.Frontiers in cardiovascular medicine · 2022Article
- Acute and long-term efficacy of ablation index-guided higher power shorter duration ablation in patients with atrial fibrillation: A prospective registry.Journal of arrhythmia · 2021Article
- Characterizing clinical outcomes and factors associated with conduction gaps in VISITAG SURPOINT-guided catheter ablation for atrial fibrillation.Journal of arrhythmia · 2021Article
- Optimal ablation index parameters for radiofrequency ablation therapy of atrial fibrillation.Pakistan journal of medical sciencesArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe ablation index (AI) is a recently developed marker for ablation lesion quality that incorporates contact force (CF), time, and power in a weighted formula. There is a paucity of information on whether AI-guided pulmonary vein isolation (PVI) could improve the outcome in patients with atrial fibrillation (AF). We evaluated the optimal AI threshold for avoiding acute pulmonary vein reconnection (PVR), and to compare the efficacy of optimal AI-targeted PVI with that of conventional CF-guided PVI.
methodsSeventy patients with AF (paroxysmal, 67%) were enrolled. In a phase 1 study, the patients underwent conventional CF-guided PVI (CON group), and the optimal AI threshold for avoiding acute PVR was identified. In phase 2, the patients underwent AI-guided PVI (OAI group). We compared the acute PVR rate between the CON group and the OAI group to demonstrate the efficacy of AI-guided PVI.
resultsIn phase 1 (n = 38), acute PVR was observed in 57 of 532 (10.7%) segments. AI values of ≥ 450 at the anterior/roof segments and of ≥ 350 at the posterior/inferior/carina segments were identified as the optimal AI thresholds for avoiding acute PVR. In the phase 2 study targeting those AI values, the OAI group (n = 32) showed a significantly lower acute PVR rate than the CON group (4.2% vs. 10.7%, p < 0.001). The OAI group showed a higher minimum AI and smaller variations in AI values than the CON group.
conclusionsOptimal AI-targeted PVI is feasible and could improve the acute outcome in patients with AF.
trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT03389074.
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