ArticleScientific reports2019
Misophonia is associated with altered brain activity in the auditory cortex and salience network.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06333925 (Using Neurostimulation to Accelerate Change in Misophonia), which is not on this map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Misophonia: A Systematic Review of Current and Future Trends in This Emerging Clinical Field.International journal of environmental research and public health · 2022Pooled it
- MDMA for the treatment of misophonia, a proposal.Frontiers in psychiatry · 2022Pooled it
- Differential brain responses to affective sounds in misophonia and hyperacusis: A task-based fMRI approach.Cognitive, affective & behavioral neuroscience · 2026Article
- Patterns of shared and differential neural activity in misophonia and non-misophonic clinical emotional dysregulation.BMC psychiatry · 2026Article
- Misophonia severity in university students: associations with negative emotionality, motor impulsivity, and checking.BMC psychology · 2026Article
- Selective Disruption of Salience-Network Anterior Insula Connectivity in Misophonia: A Disorder-Specific Neural Signature.Human brain mapping · 2026Article
- Relationships Between Autistic Trait Dimensions and Speech Understanding, Affective Sound Intolerance, and Self-Reported Hearing Difficulties.Autism in adulthood · 2026Article
- Misophonia symptom severity is linked to impaired flexibility and heightened rumination.British journal of psychology (London, England : 1953) · 2026Article
- Sensory Processing, Dissociation, and Affective Symptoms in Misophonia: A Cross-Sectional Study of 35 Adults.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Sound-evoked pupil dilation quantifies misophonic symptoms.PloS one · 2026Article
- A Comparison of Misophonia and Autistic Traits in Parents of Children with and without Autism Spectrum Disorder.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Article
- Sparse machine learning of resting-state fMRI reveals brain-wide dysconnectivity in hyperacusis.Communications medicine · 2025Article
- When Everyday Sounds Become Barriers: The Effect of Misophonia on Speech Perception.Brain and behavior · 2025Article
- The relationship between cognitive disengagement syndrome and misophonia in children with attention deficit hyperactivity disorder: the mediating role of cognitive disengagement syndrome symptoms.Annals of general psychiatry · 2025Article
- Cognitive Behavioural Therapy (CBT) for Managing Tinnitus, Hyperacusis, and Misophonia: The 2025 Tonndorf Lecture.Brain sciences · 2025Article
- Clinical Considerations for Integrating Ethical Principles of Beneficence in the Development of Evidence-Based Interventions: The case of Pediatric Misophonia.Research on child and adolescent psychopathology · 2025Review
- Mental Health Difficulties in Children who Develop Misophonia: An Examination of ADHD, Depression & Anxiety.Child psychiatry and human development · 2025Article
- The dark sides of the brain: A systematic review and meta-analysis of functional neuroimaging studies on trait aggressionAggression and violent behavior · 2025Article
- Article
- The Impact of Disgusting Sounds on Pupil Diameter of Misophonic and Non-Misophonic Listeners.Psychophysiology · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Misophonia is characterized by intense rage and disgust provoked by hearing specific human sounds resulting in social isolation due to avoidance. We exposed patients with symptom provoking audiovisual stimuli to investigate brain activity of emotional responses. 21 patients with misophonia and 23 matched healthy controls were recruited at the psychiatry department of the Amsterdam UMC. Participants were presented with three different conditions, misophonia related cues (video clips with e.g. lip smacking and loud breathing), aversive cues (violent or disgusting clips from movies), and neutral cues (video clips of e.g. someone meditating) during fMRI. Electrocardiography was recorded to determine physiological changes and self-report measures were used to assess emotional changes. Misophonic cues elicited anger, disgust and sadness in patients compared to controls. Emotional changes were associated with increases in heart rate. The neuroimaging data revealed increased activation of the right insula, right anterior cingulate cortex and right superior temporal cortex during viewing of the misophonic video clips compared to neutral clips. Our results demonstrate that audiovisual stimuli trigger anger and physiological arousal in patients with misophonia, associated with activation of the auditory cortex and salience network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.