Evidence map›Paper›PMID 31101877›Full record

ArticleScientific reports2019

The Cdh5-CreERT2 transgene causes conditional Shb gene deletion in hematopoietic cells with consequences for immune cell responses to tumors.

Qi He, Xiujuan Li, Kailash Singh, Zhengkang Luo, Mariela Meija-Cordova, Maria Jamalpour, Björn Lindahl, Vitezslav Kriz, Reetta Vuolteenaho, Maria Ulvmar and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  8. The in vivo endothelial cell translatome is highly heterogeneous across vascular beds.Proceedings of the National Academy of Sciences of the United States of America · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Qi HeDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Xiujuan LiDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-2689-1193
Kailash SinghDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-6771-7757
Zhengkang LuoDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Mariela Meija-CordovaDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Maria JamalpourDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Björn LindahlDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-0917-7075
Vitezslav KrizInstitute of Molecular Genetics of the CAS, Prague, Czech Republic.
Reetta VuolteenahoTransgenic Animals Facility, Oulu University, Oulu, Finland.
Maria UlvmarDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0002-9050-0978
Michael WelshDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden. Michael.welsh@mcb.uu.se.ORCID http://orcid.org/0000-0002-5467-9755
Uppsala University · SECzech Academy of Sciences, Institute of Molecular Genetics · CZUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tamoxifen-responsive conditional Cdh5-CreERT2 is commonly used for endothelial cell specific conditional deletion of loxP-flanked gene sequences. To address the role of endothelial cell Shb gene for B16F10 melanoma immune responses, tamoxifen-injected Cdh5-CreERT2/WT and Cdh5-CreERT2/Shb

Indexed as

Gene DeletionAnimalsAntigens, CDBone Marrow TransplantationCadherin 5CadherinsCell Line, TumorCell ProliferationDisease Models, AnimalEndothelial CellsHematopoietic Stem CellsHematopoietic Stem Cell TransplantationMelanoma, ExperimentalMiceMice, Inbred C57BLMice, TransgenicAntigens, CDCadherin 5CadherinsProto-Oncogene ProteinsShb protein, mouseTamoxifen

Identifiers

PMID31101877
PMCPMC6525206
OpenAlexW2945945230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.