Evidence map›Paper›PMID 31101854›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2019

Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.

Huishi Toh, Alexander Smolentsev, Rachel V Bozadjian, Patrick W Keeley, Madison D Lockwood, Ryan Sadjadi, Dennis O Clegg, Barbara A Blodi, Peter J Coffey, Benjamin E Reese and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

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  19. Three-dimensional remodeling of functional cerebrovascular architecture and gliovascular unit in leptin receptor-deficient mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Huishi TohCenter for Stem Cell Biology and Engineering, University of California at Santa Barbara, Santa Barbara, CA, USA. toh@ucsb.edu.ORCID http://orcid.org/0000-0002-8843-8263
Alexander SmolentsevCenter for Stem Cell Biology and Engineering, University of California at Santa Barbara, Santa Barbara, CA, USA.
Rachel V BozadjianNeuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA.
Patrick W KeeleyNeuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA.
Madison D LockwoodCenter for Stem Cell Biology and Engineering, University of California at Santa Barbara, Santa Barbara, CA, USA.
Ryan SadjadiCenter for Stem Cell Biology and Engineering, University of California at Santa Barbara, Santa Barbara, CA, USA.
Dennis O CleggCenter for Stem Cell Biology and Engineering, University of California at Santa Barbara, Santa Barbara, CA, USA.
Barbara A BlodiUniversity of Wisconsin Fundus Photograph Reading Center, University of Wisconsin, Madison, WI, USA.
Peter J CoffeyCenter for Stem Cell Biology and Engineering, University of California at Santa Barbara, Santa Barbara, CA, USA.
Benjamin E ReeseNeuroscience Research Institute, University of California at Santa Barbara, Santa Barbara, CA, USA.
James A ThomsonCenter for Stem Cell Biology and Engineering, University of California at Santa Barbara, Santa Barbara, CA, USA. jthomson@morgridgeinstitute.org.
University of California, Santa Barbara · USUniversity of Wisconsin–Madison · USMoorfields Eye Hospital NHS Foundation Trust · GB

Funding

Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI POLLAK, SETH D · 2016 to 2020
$6.0M
Development of Retinal Bipolar CellsR01EY019968 · NEI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI REESE, BENJAMIN E · 2010 to 2023
$4.9M
NEI NIH HHS R01 EY019968NICHD NIH HHS U54 HD090256
6 · The paper itself

Abstract

Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an understanding of the pathogenesis of the disease has been hampered by a lack of accurate animal models. Here, we explore the dynamics of retinal cellular changes in the Nile rat (Arvicanthis niloticus), a carbohydrate-sensitive model for type 2 diabetes. The early retinal changes in diabetic Nile rats included increased acellular capillaries and loss of pericytes that correlated linearly with the duration of diabetes. These vascular changes occurred in the presence of microglial infiltration but in the absence of retinal ganglion cell loss. After a prolonged duration of diabetes, the Nile rat also exhibits a spectrum of retinal lesions commonly seen in the human condition including vascular leakage, capillary non-perfusion, and neovascularization. Our longitudinal study documents a range and progression of retinal lesions in the diabetic Nile rat remarkably similar to those observed in human diabetic retinopathy, and suggests that this model will be valuable in identifying new therapeutic strategies.

Indexed as

AnimalsCapillariesDiabetic RetinopathyDisease ProgressionEdemaLongitudinal StudiesMurinaeRetina

Identifiers

PMID31101854
PMCPMC6788790
OpenAlexW2945862840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.