ArticleScientific reports2019
Comparison of cytotoxicity and membrane efflux pump inhibition in HepG2 cells induced by single-walled carbon nanotubes with different length and functional groups.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Cytometry in the Short-Wave Infrared.ACS nano · 2024Article
- Cell-Tissue Interaction: The Biomimetic Approach to Design Tissue Engineered Biomaterials.Bioengineering (Basel, Switzerland) · 2023Review
- Carbon nanostructures: a comprehensive review of potential applications and toxic effects.3 Biotech · 2022Review
- Controlled Supramolecular Assembly Inside Living Cells by Sequential Multistaged Chemical Reactions.Journal of the American Chemical Society · 2020Article
- Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers.International journal of nanomedicine · 2019Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental risk of single-walled carbon nanotubes (SWCNTs) is receiving increasing attentions owing to their wide study and application. However, little is known on the influence of length and functional groups on SWCNT cytotoxicity. In this study, six types of SWCNTs with different functional groups (pristine, carboxyl group and hydroxyl group) and lengths (1-3 μm and 5-30 μm) were chosen. Cytotoxicities in human hepatoma HepG2 cells induced by these SWCNTs were compared based on cell viability, oxidative stress, plasma membrane fluidity and ABC transporter activity assays. Results showed that all the SWCNTs decreased cell viability of HepG2, increased intracellular reactive oxygen species (ROS) level, and damaged plasma membrane in a concentration-dependent manner. Long SWCNTs had stronger cytotoxic effects than short SWCNTs, which might be due to weaker aggregation for the long SWCNTs. Functionalization changed the toxic effects of the SWCNTs, and different influence was found between long SWCNTs and short SWCNTs. Moreover, the six types of SWCNTs at low concentrations changed plasma membrane fluidity, inhibited transmembrane ABC transporter (efflux pump) activity, and acted as chemosensitizer to improve the sensitivity of cells to arsenic, indicating the chemosensitive effect should be considered as toxic endpoint of SWCNTs. Comparison of different toxic endpoints among the six types of SWCNTs showed that short hydroxyl-SWCNT might be safer than other SWCNTs. This study provides insights into toxicities of SWCNTs, which is of great value for the risk assessment and application of SWCNTs.
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Registered trials
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