ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019
In Vivo Synaptic Density Imaging with
Open access · bronzeAbstract read
In one paragraph
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 85 citations in OpenAlex.
- A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer's disease.Alzheimer's research & therapy · 2024Trial
- Review
- HIV-1 Tat expression drives progressive synaptic decline: evidence from longitudinal [NeuroImmune pharmacology and therapeutics · 2026Article
- PET Head Motion Estimation Using Supervised Deep Learning With Attention.IEEE transactions on medical imaging · 2026Article
- Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses.Acta neuropathologica communications · 2026Article
- [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Assessing non-invasive quantitative methods for [European journal of nuclear medicine and molecular imaging · 2025Article
- SV2A is expressed in synapse subpopulations in mouse and human brain: implications for PET radiotracer studies.Wellcome open research · 2025Article
- Molecular connectivity studies in neurotransmission: a scoping review.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Advances in synaptic PET imaging and intervention with synapse-targeted small-molecular drugs for dementia diagnosis and therapy.Fundamental research · 2025Review
- Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity.Journal of neurotrauma · 2024Article
- Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Conditional knockout of AIM2 in microglia ameliorates synaptic plasticity and spatial memory deficits in a mouse model of Alzheimer's disease.CNS neuroscience & therapeutics · 2024Article
- Dual Drug Repurposing: The Example of Saracatinib.International journal of molecular sciences · 2024Review
- A single subanaesthetic dose of the rapid-acting antidepressant S-ketamine raises presynaptic SV2A density in limbic regions of the Wistar Kyoto rat model of depression.Neuroscience applied · 2024Article
- Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [Movement disorders : official journal of the Movement Disorder Society · 2023Observational
- Detecting Early Cognitive Decline in Alzheimer's Disease with Brain Synaptic Structural and Functional Evaluation.Biomedicines · 2023Review
- Technical opportunities and challenges in developing total-body PET scanners for mice and rats.EJNMMI physics · 2023Review
- Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [Frontiers in neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Takuya ToyonagaPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut takuya.toyonaga@yale.edu.
Levi M SmithDepartment of Cell Biology, Yale University School of Medicine, New Haven, Connecticut.
Sjoerd J FinnemaPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Jean-Dominique GallezotPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Mika NaganawaPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Jason BiniPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Tim MulnixPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Zhengxin CaiPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Jim RopchanPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Yiyun HuangPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Stephen M StrittmatterProgram in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut; and.
Richard E CarsonPET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut.
Yale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8MPrion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6MSilent Allosteric Modulation of mGluR5 for Safe and Effective Therapy of Alzheimer's DiseaseU01AG058608 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2018 to 2022
$8.5MYale Alzheimer Disease Research CenterP50AG047270 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2015 to 2019
$8.3MCharacterizing and Targeting Pyk2 Kinase in Alzheimer’s DiseaseRF1AG053000 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2016 to 2016
$2.1MState-of-the-Art Small Animal PET/CT InstrumentationS10OD010322 · OD · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2013 to 2013
$595kNCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NIA NIH HHS P50 AG047270NIA NIH HHS R01 AG034924NIA NIH HHS RF1 AG053000NIA NIH HHS U01 AG058608NIH HHS S10 OD010322
Abstract
PubMed holds no abstract for this paper.
Indexed as
Positron-Emission TomographyPyridinesPyrrolidinesAlzheimer DiseaseAnimalsBenzodioxolesDisease Models, AnimalFemaleKineticsMaleMicePyrrolidinonesQuinazolinesSynapses1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneBenzodioxolesPyridinesPyrrolidinesPyrrolidinonesQuinazolinessaracatinib11C-UCB-J PETAlzheimer diseasesaracatinib (AZD0530)SV2Asynaptic density
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.