Evidence map›Paper›PMID 31101674›Full record

ArticleThe EMBO journal2019

Live-cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting.

Benjamin T Donovan, Anh Huynh, David A Ball, Heta P Patel, Michael G Poirier, Daniel R Larson, Matthew L Ferguson, Tineke L Lenstra

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 228 citations in OpenAlex.

  1. Article
  2. Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Establishing MS2-MCP-based single-molecule RNA visualization inbioRxiv : the preprint server for biology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. What makes genes burst.Trends in cell biology · 2026
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Benjamin T DonovanBiophysics Graduate Program, The Ohio State University, Columbus, OH, USA.
Anh HuynhDepartment of Physics, Boise State University, Boise, ID, USA.
David A BallLaboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD, USA.
Heta P PatelDivision of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Michael G PoirierBiophysics Graduate Program, The Ohio State University, Columbus, OH, USA.
Daniel R LarsonLaboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD, USA.
Matthew L FergusonDepartment of Physics, Boise State University, Boise, ID, USA mattferguson@boisestate.edu t.lenstra@nki.nl.ORCID 0000-0003-0760-757X
Tineke L LenstraDivision of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands mattferguson@boisestate.edu t.lenstra@nki.nl.ORCID 0000-0002-4440-9962
Boise State University · USNational Institutes of Health · USThe Netherlands Cancer Institute · NLThe Ohio State University · US

Funding

Transcription Dynamics in Single CellsZIABC011383 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LARSON, DANIEL · 2011 to 2025
$23.8M
Cellular, molecular, and biochemical sciences training grantT32GM086252 · NIGMS · OHIO STATE UNIVERSITY · PI JACKMAN, JANE ELIZABETH, MUSIER-FORSYTH, KARIN M · 2011 to 2020
$2.0M
Mechanistic study of pioneer factorsR01GM121858 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BAI, LU · 2017 to 2020
$1.2M
Regulatory Mechanisms of Linker Histones and Their Post-Translational ModificationsR01GM121966 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2017 to 2020
$1.2M
Spatiotemporal Dynamics of Transcription and Splicing by Two Photon 3D Orbital TrackingR15GM123446 · NIGMS · BOISE STATE UNIVERSITY · PI FERGUSON, MATTHEW LEE · 2017 to 2023
$900k
A Systems Biology Approach for Targeted Drug Discovery for LeishmaniasisR21AI127582 · NIAID · OHIO STATE UNIVERSITY · PI IBBA, MICHAEL, SATOSKAR, ABHAY R · 2017 to 2018
$401k
NIAID NIH HHS R21 AI127582NIGMS NIH HHS R01 GM121858NIGMS NIH HHS R01 GM121966NIGMS NIH HHS R15 GM123446NIGMS NIH HHS T32 GM086252
6 · The paper itself

Abstract

Transcription factors show rapid and reversible binding to chromatin in living cells, and transcription occurs in sporadic bursts, but how these phenomena are related is unknown. Using a combination of

Indexed as

Transcriptional ActivationBinding SitesCarbohydrate MetabolismGalactokinaseGalactoseGene Expression Regulation, FungalMolecular ImagingNucleosomesOrganisms, Genetically ModifiedProtein BindingSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSingle-Cell AnalysisTrans-ActivatorsTranscription FactorsTranscription, GeneticGAL10 protein, S cerevisiaeGAL1 protein, S cerevisiaeGal3 protein, S cerevisiaeGalactokinaseGalactoseNucleosomesSaccharomyces cerevisiae ProteinsTrans-ActivatorsTranscription Factorsbinding dynamicsburst sizechromatinstochastictranscriptional activators

Identifiers

PMID31101674
PMCPMC6576174
OpenAlexW2946478090

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.