ArticleJournal of biomechanics2019
Can altered muscle synergies control unimpaired gait?
Article in Journal of biomechanics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Adult spinal deformity is associated with reduced muscle synergies.Spine deformity · 2026Article
- Adaptive alterations in muscle synergies during the recovery step compensate for perturbation-induced stability demands in older adults.BMC geriatrics · 2026Article
- The Differential Effects of Fast Walking Speed on Muscle Coactivation in the Paretic and Non-Paretic Extremities Post-Stroke.Neurorehabilitation and neural repair · 2026Article
- Muscle Tendon Passive Parameter Estimation Using Musculoskeletal Optimal Control.Annals of biomedical engineering · 2026Article
- Estimating the contribution of musculoskeletal impairments to altered gait kinematics in children with cerebral palsy using predictive simulations.Journal of neuroengineering and rehabilitation · 2025Article
- Generalizability of neuromuscular coordination in the human upper extremity after stroke and its implications in neurorehabilitation.Journal of neuroengineering and rehabilitation · 2025Article
- Muscle Synergies of the Lower Extremities During Gait Initiation in Individuals With and Without Chronic Ankle Instability.Journal of foot and ankle research · 2025Article
- Aging-related changes in neuromuscular control strategies and their influence on postural stability.Scientific reports · 2025Article
- A PRISMA systematic review through time on predictive musculoskeletal simulations.Journal of neuroengineering and rehabilitation · 2025Article
- Motor modules are largely unaffected by pathological walking biomechanics: a simulation study.Journal of neuroengineering and rehabilitation · 2025Article
- Piloting a Novel Computational Framework for Identifying Prosthesis-Specific Contributions to Gait Deviations.International journal for numerical methods in biomedical engineering · 2024Article
- Does crouch alter the effects of neuromuscular impairments on gait? A simulation study.Journal of biomechanics · 2024Article
- A Study of Racket Weight Adaptation in Advanced and Beginner Badminton Players.Applied bionics and biomechanics · 2024Article
- Optimal fibre length and maximum isometric force are the most influential parameters when modelling muscular adaptations to unloading using Hill-type muscle models.Frontiers in physiology · 2024Article
- Motor control complexity can be dynamically simplified during gait pattern exploration using motor control-based biofeedback.Journal of neurophysiology · 2023Article
- Number of synergies impacts sensitivity of gait to weakness and contracture.Journal of biomechanics · 2022Article
- Muscle synergy analysis yields an efficient and physiologically relevant method of assessing stroke.Brain communications · 2022Article
- Clarify Sit-to-Stand Muscle Synergy and Tension Changes in Subacute Stroke Rehabilitation by Musculoskeletal Modeling.Frontiers in systems neuroscience · 2022Article
- Article
- OpenSim Moco: Musculoskeletal optimal control.PLoS computational biology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent studies have postulated that the human motor control system recruits groups of muscles through low-dimensional motor commands, or muscle synergies. This scheme simplifies the neural control problem associated with the high-dimensional structure of the neuromuscular system. Several lines of evidence have suggested that neurological injuries, such as stroke or cerebral palsy, may reduce the dimensions that are available to the motor control system, and these altered dimensions or synergies are thought to contribute to impaired walking patterns. However, no study has investigated whether impaired low-dimensional control spaces necessarily lead to impaired walking patterns. In this study, using a two-dimensional model of walking, we developed a synergy-based control framework that can simulate the dynamics of walking. The simulation analysis showed that a synergy-based control scheme can produce well-coordinated movements of walking matching unimpaired gait. However, when the dimensions available to the controller were reduced, the simplified emergent pattern deviated from unimpaired gait. A system with two synergies, similar to those seen after neurological injury, could not produce an unimpaired walking pattern. These findings provide further evidence that altered muscle synergies can contribute to impaired gait patterns and may need to be directly addressed to improve gait after neurological injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.