ArticleVirology journal2019
Serological evidence of Flavivirus circulation in human populations in Northern Kenya: an assessment of disease risk 2016-2017.
Article in Virology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The magnitude of flaviviruses infection in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review.PLoS neglected tropical diseases · 2024Pooled it
- Epidemiology of yellow fever virus in humans, arthropods, and non-human primates in sub-Saharan Africa: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2022Pooled it
- Epidemiology of West Nile virus in Africa: An underestimated threat.PLoS neglected tropical diseases · 2022Pooled it
- Dengue Virus Infection in Sub-Saharan Africa Between 2010 and 2020: A Systematic Review and Meta-Analysis.Frontiers in cellular and infection microbiology · 2021Pooled it
- Isolation and molecular characterization of West Nile Virus with evidence of vertical transmission in the Coastal region, Kenya.Microbiology spectrum · 2026Article
- Structural and nonstructural protein divergence correlates with strain-specific vector competence for Zika virus.Parasites & vectors · 2026Article
- A systematic review and meta-analysis of Zika virus epidemiology.Nature health · 2026Article
- Serological Evidence of Flavivirus Infection Among Mothers of Newborns in El Paso, Texas.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2025Article
- Article
- Characterization of West Nile virus Koutango lineage from phlebotomine sandflies in Kenya.PloS one · 2024Article
- Seroprevalence of dengue, yellow fever, and related flaviviruses among the rural human population in Nguruman and Kerio Valley, Kenya.Frontiers in virology (Lausanne, Switzerland) · 2024Article
- Assessing yellow fever outbreak potential and implications for vaccine strategy.PLOS global public health · 2024Article
- Interaction of Human Behavioral Factors Shapes the Transmission of Arboviruses byPathogens (Basel, Switzerland) · 2023Review
- Flavivirus Antibodies Reactive to Zika Virus Detected in Multiple Species of Nonhuman Primates in Kenya, 2008-2017.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2023Article
- Article
- Arthropod-borne diseases among travellers arriving in Europe from Africa, 2015 to 2019.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023Article
- Circulation of Ngari Virus in Livestock, Kenya.mSphere · 2022Article
- Prevalence of microcephaly and Zika virus infection in a pregnancy cohort in Kenya, 2017-2019.BMC medicine · 2022Article
- Uncovering the Burden of Dengue in Africa: Considerations on Magnitude, Misdiagnosis, and Ancestry.Viruses · 2022Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundYellow fever, Dengue, West Nile and Zika viruses are re-emerging mosquito-borne Flaviviruses of public health concern. However, the extent of human exposure to these viruses and associated disease burden in Kenya and Africa at large remains unknown. We assessed the seroprevalence of Yellow fever and other Flaviviruses in human populations in West Pokot and Turkana Counties of Kenya. These areas border Uganda, South Sudan and Ethiopia where recent outbreaks of Yellow fever and Dengue have been reported, with possibility of spillover to Kenya. METHODOLOGY: Human serum samples collected through a cross-sectional survey in West Pokot and Turkana Counties were screened for neutralizing antibodies to Yellow fever, Dengue-2, West Nile and Zika virus using the Plaque Reduction Neutralization Test (PRNT). Seroprevalence was compared by county, site and important human demographic characteristics. Adjusted odds ratios (aOR) were estimated using Firth logistic regression model.
resultsOf 877 samples tested, 127 neutralized with at least one of the four flaviviruses (14.5, 95% CI 12.3-17.0%), with a higher proportion in Turkana (21.1%, n = 87/413) than in West Pokot (8.6%, n = 40/464). Zika virus seroprevalence was significantly higher in West Pokot (7.11%) than in Turkana County (0.24%; χ
conclusionEvidence of neutralizing antibodies to West Nile and Zika viruses indicates that they have been circulating undetected in human populations in these areas. While the observed Yellow Fever prevalence in Turkana and West Pokot Counties may imply virus activity, we speculate that this could also be as a result of vaccination following the Yellow Fever outbreak in the Omo river valley, South Sudan and Uganda across the border.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.