ArticleJournal of neuroinflammation2019
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren's syndrome.
Article in Journal of neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- The effects of resistance training in patients with primary Sjogren's syndrome.Clinical rheumatology · 2022Trial
- Fatigue in Sjögren's Disease - Integrating Biomedical and Psychosocial Aspects: A Narrative Review.Rheumatology and therapy · 2026Review
- Distinct molecular profile in Sjögren's syndrome is associated with disease activity and clinical manifestations.Scientific reports · 2026Article
- Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases.Nature reviews. Neurology · 2025Review
- Lack of Significant Associations Between Hematological Parameters, Salivary Gland Histopathology and Fatigue in Sjögren's Disease.International journal of molecular sciences · 2025Article
- Sleep Disorders in Connective Tissue Diseases-Coexisting Diseases or Disease Components?Journal of clinical medicine · 2024Review
- Depression is the most significant independent predictor of fatigue in patients with primary Sjögren's syndrome.Archives of rheumatology · 2023Article
- High mobility group box 1 and a network of other biomolecules influence fatigue in patients with Crohn's disease.Molecular medicine (Cambridge, Mass.) · 2023Article
- The Future of Targeted Treatment of Primary Sjögren's Syndrome: A Focus on Extra-Glandular Pathology.International journal of molecular sciences · 2022Review
- The Involvement of Alarmins in the Pathogenesis of Sjögren's Syndrome.International journal of molecular sciences · 2022Review
- Fatigue: a frequent and biologically based phenomenon in newly diagnosed celiac disease.Scientific reports · 2022Article
- Fatigue in inflammatory rheumatic diseases: current knowledge and areas for future research.Nature reviews. Rheumatology · 2021Review
- Expression of and correlational patterns among neuroinflammatory, neuropeptide, and neuroendocrine molecules from cerebrospinal fluid in cerebral palsy.BMC neurology · 2021Article
- Sample Preparation Strategies for Antibody-Free Quantitative Analysis of High Mobility Group Box 1 Protein.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression.Translational psychiatry · 2021Article
- Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn's disease.Innate immunity · 2021Article
- Sjogren's Syndrome and Pulmonary Disease.Advances in experimental medicine and biology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFatigue is a common and sometimes debilitating phenomenon in primary Sjögren's syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide hypocretin-1 (Hcrt1), a regulator of wakefulness, influence fatigue.
methodsHcrt1 was measured by radioimmunoassay (RIA) in cerebrospinal fluid (CSF) from 49 patients with pSS. Interleukin-1 receptor antagonist (IL-1Ra), IL-1 receptor type 2 (IL-1RII), IL-6, and S100B protein were measured by enzyme-linked immunosorbent assay (ELISA). Fatigue was rated by the fatigue visual analog scale (fVAS).
resultsSimple univariate regression and multiple regression analyses with fatigue as a dependent variable revealed that depression, pain, and the biochemical variable IL-1Ra had a significant association with fatigue. In PCA, two significant components were revealed. The first component (PC1) was dominated by variables related to IL-1β activity (IL-1Ra, IL-1RII, and S100B). PC2 showed a negative association between IL-6 and Hcrt1. fVAS was then introduced as an additional variable. This new model demonstrated that fatigue had a higher association with the IL-1β-related PC1 than to PC2. Additionally, a third component (PC3) became significant between low Hcrt1 concentrations and fVAS scores.
conclusionsThe main findings of this study indicate a functional network in which several IL-1β-related molecules in CSF influence fatigue in addition to the classical clinical factors of depression and pain. The neuropeptide Hcrt1 seems to participate in fatigue generation, but likely not through the IL-1 pathway.
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