Evidence map›Paper›PMID 31100969›Full record

ReviewAntioxidants (Basel, Switzerland)2019

Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension.

Ruslan Rafikov, Joel James, Nolan McClain, Stevan P Tofovic, Olga Rafikova

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex.Translational research : the journal of laboratory and clinical medicine · 2022
    Article
  4. Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ruslan RafikovDivision of Endocrinology, University of Arizona, Tucson, AZ 85721, USA. ruslanrafikov@email.arizona.edu.
Joel JamesDivision of Endocrinology, University of Arizona, Tucson, AZ 85721, USA. joeljames@deptofmed.arizona.edu.
Nolan McClainDivision of Endocrinology, University of Arizona, Tucson, AZ 85721, USA. nolanm@email.arizona.edu.
Stevan P TofovicDepartment of Pharmacology and Chemical Biology, Vascular Medicine Institute, University of Pittsburgh, Pennsylvania, PA 15260, USA. tofovic@pitt.edu.
Olga RafikovaDivision of Endocrinology, University of Arizona, Tucson, AZ 85721, USA. orafikova@email.arizona.edu.
University of Arizona · USUniversity of Pittsburgh · US

Funding

Anaplerotic reprogramming of endothelial cells in pulmonary hypertension.R01HL132918 · NHLBI · UNIVERSITY OF ARIZONA · PI RAFIKOV, RUSLAN · 2016 to 2025
$4.5M
HMGBG1 and Gender Difference in Pulmonary Arterial HypertensionR01HL133085 · NHLBI · UNIVERSITY OF ARIZONA · PI RAFIKOVA, OLGA · 2016 to 2020
$1.9M
NHLBI NIH HHS R01 HL132918NHLBI NIH HHS R01 HL133085NIH HHS R01HL132918NIH HHS R01HL133085
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology.

Indexed as

antioxidantsgender differenceoxidationpulmonary hypertensionredox homeostasis

Identifiers

PMID31100969
PMCPMC6562572
OpenAlexW2945267011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.