Evidence map›Paper›PMID 31100929›Full record

ReviewInternational journal of molecular sciences2019

Dysbiosis Disrupts Gut Immune Homeostasis and Promotes Gastric Diseases.

Devinder Toor, Mishi Kaushal Wsson, Prashant Kumar, G Karthikeyan, Naveen Kumar Kaushik, Chhavi Goel, Sandhya Singh, Anil Kumar, Hridayesh Prakash

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 4 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 4 syntheses or guidelines pooled it, 171 citations in OpenAlex.

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  10. Association between Broad-Spectrum Antibiotic Use and Risk of Early-Onset Colorectal Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Devinder ToorAmity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. dtoor@amity.edu.
Mishi Kaushal WssonAmity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. mwasson@amity.edu.
Prashant KumarAmity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. pkumar18@amity.edu.
G KarthikeyanAmity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. gkarthikeyan@amity.edu.
Naveen Kumar KaushikAmity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. nkkaushik@amity.edu.
Chhavi GoelAmity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. cgoel@amity.edu.
Sandhya SinghDepartment of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telengana, India. sandhya_singh1@yahoo.com.
Anil KumarNational Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. anilk@nii.ac.in.
Hridayesh PrakashAmity Institute of Virology and Immunology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. hprakash@amity.edu.
Amity University · INNational Institute of Immunology · INUniversity of Hyderabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perturbation in the microbial population/colony index has harmful consequences on human health. Both biological and social factors influence the composition of the gut microbiota and also promote gastric diseases. Changes in the gut microbiota manifest in disease progression owing to epigenetic modification in the host, which in turn influences differentiation and function of immune cells adversely. Uncontrolled use of antibiotics, chemotherapeutic drugs, and any change in the diet pattern usually contribute to the changes in the colony index of sensitive strains known to release microbial content in the tissue micromilieu. Ligands released from dying microbes induce Toll-like receptor (TLR) mimicry, skew hypoxia, and cause sterile inflammation, which further contributes to the severity of inflammatory, autoimmune, and tumorous diseases. The major aim and scope of this review is both to discuss various modalities/interventions across the globe and to utilize microbiota-based therapeutic approaches for mitigating the disease burden.

Indexed as

HomeostasisAnimalsAnti-Bacterial AgentsAntineoplastic AgentsAutoimmune DiseasesDietDysbiosisGastrointestinal MicrobiomeHost Microbial InteractionsHumansHypoxiaInflammationMacrophagesStomach DiseasesToll-Like ReceptorsAnti-Bacterial AgentsAntineoplastic AgentsToll-Like Receptorsgut microbiotaimmune epigeneticsmacrophagesmetabolismsterile inflammationTLR mimicry

Identifiers

PMID31100929
PMCPMC6567003
OpenAlexW2945009338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.