ArticleMolecules (Basel, Switzerland)2019
Antihypertensive Effects of Corn Silk Extract and Its Novel Bioactive Constituent in Spontaneously Hypertensive Rats: The Involvement of Angiotensin-Converting Enzyme Inhibition.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 41 citations in OpenAlex.
- Corn silk extract as a prebiotic exerts antihypertensive effects via gut microbiota modulation in hypertensive rats.Microbiology spectrum · 2026Article
- Bioactive Peptides from Corn (Biology · 2024Review
- An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review.Molecules (Basel, Switzerland) · 2024Review
- Effects of Foods of Mesoamerican Origin in Adipose Tissue and Liver-Related Metabolism.Medicina (Kaunas, Lithuania) · 2023Review
- Affinity Purification and Molecular Characterization of Angiotensin-Converting Enzyme (ACE)-Inhibitory Peptides fromMarine drugs · 2023Article
- Nutritional, bioactive components and health properties of the milpa triad system seeds (corn, common bean and pumpkin).Frontiers in nutrition · 2023Review
- Extraction Optimization, Preliminary Identification, and Bioactivities in Corn Silk.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Lemon Balm and Corn Silk Mixture Alleviates Metabolic Disorders Caused by a High-Fat Diet.Antioxidants (Basel, Switzerland) · 2022Article
- Purification, Identification and Characterization of Antioxidant Peptides from Corn Silk Tryptic Hydrolysate: An Integrated In Vitro-In Silico Approach.Antioxidants (Basel, Switzerland) · 2021Article
- Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β-catenin signaling pathway.Food science & nutrition · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Corn silk tea has been used in folk medicine for anti-hypertensive healthcare. Angiotensin-converting enzyme (ACE) plays a crucial role on the homeostasis of blood pressure. However, effects of corn silk tea on ACE activity and the presence of ACE inhibitory constituents in corn silk are still unknown. Here we applied proteomics and bioinformatics approaches to identify corn silk bioactive peptides (CSBps) that target ACE from the boiling water extract of corn silk (CSE). CSE significantly reduced systolic blood pressure (SBP) levels in spontaneously hypertensive rats and inhibited the ACE activity. By proteomics coupled with bioinformatics analyses, we identified a novel ACE inhibitory peptide CSBp5 in CSE. CSBp5 significantly inhibited the ACE activity and decreased SBP levels in a dose-dependent manner. Docking analysis showed that CSBp5 occupied the substrate-binding channel of ACE and interacted with ACE via hydrogen bonds. In conclusion, we identified that CSE exhibited anti-hypertensive effects in SHRs via the inhibition of ACE, the target of most anti-hypertensive drugs. In addition, an ACE inhibitory phytopeptide CSBp5 that decreased SBP levels in rats was newly identified. Our findings supported the ethnomedical use of corn silk tea on hypertension. Moreover, the identification of ACE inhibitory phytopeptide in corn silk further strengthened our findings.
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