Evidence map›Paper›PMID 31100911›Full record

ArticleCells2019

Leucocyte Telomere Length and Glucose Tolerance Status in Mixed-Ancestry South Africans.

Cecil J Weale, Glenda M Davison, Gloudina M Hon, Andre P Kengne, Rajiv T Erasmus, Tandi E Matsha

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Cecil J WealeSAMRC/CPUT/Cardiometabolic Health Research unit, Department of Biomedical sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7530, South Africa. cecilweale@gmail.com.
Glenda M DavisonSAMRC/CPUT/Cardiometabolic Health Research unit, Department of Biomedical sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7530, South Africa. davisong@cput.ac.za.ORCID 0000-0003-2726-8114
Gloudina M HonSAMRC/CPUT/Cardiometabolic Health Research unit, Department of Biomedical sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7530, South Africa. HonG@cput.ac.za.
Andre P KengneNon Communicable Diseases Research Unit, South African Medical Research Council, Cape Town 7505, South Africa. Andre.Kengne@mrc.ac.za.ORCID 0000-0002-5183-131X
Rajiv T ErasmusDepartment of Pathology, Faculty of Medicine and Health Sciences, National Health Laboratory Service (NHLS) and Stellenbosch University, Cape Town 7505, South Africa. rte@sun.ac.za.
Tandi E MatshaSAMRC/CPUT/Cardiometabolic Health Research unit, Department of Biomedical sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7530, South Africa. matshat@cput.ac.za.
Cape Peninsula University of Technology · ZANational Health Laboratory Service · ZASouth African Medical Research Council · ZAUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomeres are DNA-tandem repeats situated at the ends of chromosomes and are responsible for genome stabilization. They are eroded by increased cell division, age and oxidative stress with shortened leucocyte telomeres (LTL) being associated with inflammatory disorders, including Type II diabetes. We assessed LTL in 205 participants across glucose tolerance groups at baseline and after three years in the mixed ancestry population of South Africa which have been shown to have high rates of obesity and T2DM. Baseline and follow-up data included glucose tolerance status, anthropometric measurements, lipids, insulin, γ-glutamyl transferase (GGT), cotinine, and HbA1c. Telomere length was measured using the absolute telomere q-PCR method performed on a Bio-Rad MiniOpticon Detector. No significant difference was detected in LTL across glucose tolerance groups at both time points, including in subjects who showed a deterioration of their glucose tolerance status. There was, however, a significant negative correlation between LTL and age which was more pronounced in diabetes (

Indexed as

AgedAge FactorsBlood GlucoseDiabetes Mellitus, Type 2FemaleFollow-Up Studiesgamma-GlutamyltransferaseGlucose Tolerance TestHumansHyperglycemiaInsulinLeukocytesLongitudinal StudiesMaleMiddle AgedObesityBlood Glucosegamma-Glutamyltransferasegamma-glutamyltransferase, humanInsulinhyperglycemialeucocyte telomere lengthtype II diabetes

Identifiers

PMID31100911
PMCPMC6563037
OpenAlexW2946797530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.