ArticleInternational journal of environmental research and public health2019
Combining Heart Rate Variability with Disease Severity Score Variables for Mortality Risk Stratification in Septic Patients Presenting at the Emergency Department.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A comparison of qSOFA, SIRS and NEWS in predicting the accuracy of mortality in patients with suspected sepsis: A meta-analysis.PloS one · 2022Pooled it
- National Early Warning Score Does Not Accurately Predict Mortality for Patients With Infection Outside the Intensive Care Unit: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- SOFA score combined with heart rate variability predicts in-hospital mortality in patients with intra-abdominal hypertension: a retrospective study.BMC medical informatics and decision making · 2026Article
- Developing and validating a machine learning model to predict multidrug-resistantFrontiers in immunology · 2024Article
- Heart rate variability in acute pancreatitis: a narrative review.Translational gastroenterology and hepatology · 2024Review
- Article
- Lipopolysaccharide-induced sepsis impairs M2R-GIRK signaling in the mouse sinoatrial node.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dysfunction of the Autonomic Nervous System and its Role in the Pathogenesis of Septic Critical Illness (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Heart rate n-variability (HRnV) measures for prediction of mortality in sepsis patients presenting at the emergency department.PloS one · 2021Article
- Autonomic balance determines the severity of COVID-19 courses.Bioelectronic medicine · 2020Article
- A narrative review of heart rate and variability in sepsis.Annals of translational medicine · 2020Review
- The Association of Autonomic Nervous System Function With Ischemic Stroke, and Treatment Strategies.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergency department (ED) serves as the first point of hospital contact for many septic patients, where risk-stratification would be invaluable. We devised a combination model incorporating demographic, clinical, and heart rate variability (HRV) parameters, alongside individual variables of the Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation II (APACHE II), and Mortality in Emergency Department Sepsis (MEDS) scores for mortality risk-stratification. ED patients fulfilling systemic inflammatory response syndrome criteria were recruited. National Early Warning Score (NEWS), Modified Early Warning Score (MEWS), quick SOFA (qSOFA), SOFA, APACHE II, and MEDS scores were calculated. For the prediction of 30-day in-hospital mortality, combination model performed with an area under the receiver operating characteristic curve of 0.91 (95% confidence interval (CI): 0.88-0.95), outperforming NEWS (0.70, 95% CI: 0.63-0.77), MEWS (0.61, 95% CI 0.53-0.69), qSOFA (0.70, 95% CI 0.63-0.77), SOFA (0.74, 95% CI: 0.67-0.80), APACHE II (0.76, 95% CI: 0.69-0.82), and MEDS scores (0.86, 95% CI: 0.81-0.90). The combination model had an optimal sensitivity and specificity of 91.4% (95% CI: 81.6-96.5%) and 77.9% (95% CI: 72.6-82.4%), respectively. A combination model incorporating clinical, HRV, and disease severity score variables showed superior predictive ability for the mortality risk-stratification of septic patients presenting at the ED.
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