ArticleJournal of the mechanical behavior of biomedical materials2019
Reliable preparation of agarose phantoms for use in quantitative magnetic resonance elastography.
Article in Journal of the mechanical behavior of biomedical materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Quantitative Susceptibility Mapping of Kidney Stones: An Ex Vivo MRI Phantom Study.Magnetic resonance in medicine · 2026Article
- Interface geometry governs probe insertion mechanics and electrode deviation in layered brain-mimicking phantoms for deep brain stimulation.Biomechanics and modeling in mechanobiology · 2026Article
- Temporally Delayed Deployment of Photo-Responsive Liquid Crystal Polymer Networks Toward Neural Interfaces.Advanced healthcare materials · 2026Article
- Fn14-Targeted Gold Nanorods for Augmenting Laser Thermal Therapy for High-Grade Gliomas.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Hyaluronic Acid-Coated SPIONs with Attached Folic Acid as Potential T2 MRI Contrasts for Anticancer Therapies.ACS applied materials & interfaces · 2025Article
- Development of fetal magnetic resonance imaging (MRI) phantom.Quantitative imaging in medicine and surgery · 2024Article
- Agarose as a Tissue Mimic for the Porcine Heart, Kidney, and Liver: Measurements and a Springpot Model.Bioengineering (Basel, Switzerland) · 2024Article
- Viscoelastic polyacrylamide MR elastography phantoms with tunable damping ratio independent of shear stiffness.Journal of the mechanical behavior of biomedical materials · 2024Article
- The contributions of relative brain viscosity to brain function and health.Brain communications · 2024Review
- Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review.Nanomaterials (Basel, Switzerland) · 2023Review
- Additively manufactured, solid object structures for adjustable image contrast in Magnetic Resonance Imaging.Zeitschrift fur medizinische Physik · 2022Article
- Insertion mechanics of amorphous SiC ultra-micro scale neural probes.Journal of neural engineering · 2022Article
- Correlated noise in brain magnetic resonance elastography.Magnetic resonance in medicine · 2022Article
- Quantitative effects of off-resonance related distortion on brain mechanical property estimation with magnetic resonance elastography.NMR in biomedicine · 2022Article
- Multimodal phantoms for clinical PET/MRI.EJNMMI physics · 2021Review
- Soft, Conductive, Brain-Like, Coatings at Tips of Microelectrodes Improve Electrical Stability under Chronic, In Vivo Conditions.Micromachines · 2021Article
- Lorentz force induced shear waves for magnetic resonance elastography applications.Scientific reports · 2021Article
- Physical imaging phantoms for simulation of tumor heterogeneity in PET, CT, and MRI: An overview of existing designs.Medical physics · 2020Review
- Nanobubble Liposome Complexes for Diagnostic Imaging and Ultrasound-Triggered Drug Delivery in Cancers: A Theranostic Approach.ACS omega · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Agarose phantoms are one type of phantom commonly used in developing in vivo brain magnetic resonance elastography (MRE) sequences because they are inexpensive and easy to work with, store, and dispose of; however, protocols for creating agarose phantoms are non-standardized and often result in inconsistent phantoms with significant variability in mechanical properties. Many magnetic resonance imaging (MRI) and ultrasound studies use phantoms, but often these phantoms are not tailored for desired mechanical properties and as such are too stiff or not mechanically consistent enough to be used in MRE. In this work, we conducted a systematic study of agarose phantom creation parameters to identify those factors that are most conducive to producing mechanically consistent agarose phantoms for MRE research. We found that cooling rate and liquid temperature affected phantom homogeneity. Phantom stiffness is affected by agar concentration (quadratically), by final liquid temperature and salt content in phantoms, and by the interaction of these two metrics each with stir rate. We captured and quantified the implied relationships with a regression model that can be used to estimate stiffness of resulting phantoms. Additionally, we characterized repeatability, stability over time, impact on MR signal parameters, and differences in agar gel microstructure. This protocol and regression model should prove beneficial in future MRE development studies that use phantoms to determine stiffness measurement accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.