Evidence map›Paper›PMID 31100288›Full record

ArticleToxicology and applied pharmacology2019

Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.

K A Shipkowski, J M Sanders, J D McDonald, C E Garner, M Doyle-Eisele, C J Wegerski, S Waidyanatha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology and applied pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Charge-Shifting Copolymers of 2‑(ACS applied polymer materials · 2026
    Article
  2. Isolation and characterization of a novel choline degradingCurrent research in microbial sciences · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

K A ShipkowskiDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America.
J M SandersDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America.
J D McDonaldLovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America.
C E GarnerLovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America.
M Doyle-EiseleLovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America.
C J WegerskiLovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America.
S WaidyanathaDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America. Electronic address: waidyanathas@niehs.nih.gov.
Mental Research Institute · USNational Institute of Environmental Health Sciences · US

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
NIEHS NIH HHS N01 ES075562
6 · The paper itself

Abstract

Dimethylaminoethanol (DMAE) and its salts have been used to treat numerous disorders in humans and hence safety of its use is a concern. DMAE is a close structural analog of choline, an essential nutrient. Exposure to DMAE may affect choline uptake and synthesis. The current investigation characterizes: 1) the absorption, distribution, metabolism, and excretion (ADME) of DMAE in Wistar Han rats and B6C3F1 mice following a single gavage or intravenous (IV) administration of 10, 100 or 500 mg/kg [

Indexed as

Administration, IntravenousAdministration, OralAnimalsCholineDeanolDimethylnitrosamineFemaleMaleMiceRatsRats, WistarTissue DistributionCholineDeanolDimethylnitrosamineCholineDimethylaminoethanolDispositionMetabolismN-N-dimethylnitrosamineTissue distribution

Identifiers

PMID31100288
PMCPMC7252906
OpenAlexW2945278669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.